Animal models for screening anxiolytic-like drugs: a perspective

M Bourin - Dialogues in clinical neuroscience, 2015 - Taylor & Francis
Contemporary biological psychiatry uses experimental animal models to increase our
understanding of affective disorder pathogenesis. Modern anxiolytic drug discovery mainly …

[HTML][HTML] Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology

K Tylek, E Trojan, M Regulska, E Lacivita… - Pharmacological …, 2021 - Springer
Formyl peptide receptors (FPRs) belong to the family of seven-transmembrane G protein-
coupled receptors. Among them, FPR2 is a low affinity receptor for N-formyl peptides and is …

[HTML][HTML] Placental endocrine function shapes cerebellar development and social behavior

CM Vacher, H Lacaille, JJ O'Reilly, J Salzbank… - Nature …, 2021 - nature.com
Compromised placental function or premature loss has been linked to diverse
neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a …

Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes

A Al Mamun, A Chauhan, S Qi… - Proceedings of the …, 2020 - National Acad Sciences
Microglial activation plays a central role in poststroke inflammation and causes secondary
neuronal damage; however, it also contributes in debris clearance and chronic recovery …

[HTML][HTML] Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression …

S Javaid, F Alqahtani, W Ashraf, SMM Anjum… - Biomedicine & …, 2023 - Elsevier
Abstract Tiagabine (Tia), a new-generation antiseizure drug that mimics the GABAergic
signaling by inhibiting GABA transporter type-1, is the least studied molecule in chronic …

The role of annexin A1 and formyl peptide receptor 2/3 signaling in chronic corticosterone-induced depression-like behaviors and impairment in hippocampal …

AF Peritore, R Crupi, M Scuto… - CNS & Neurological …, 2020 - ingentaconnect.com
Background: The activity of the Hypothalamic-Pituitary-Adrenal (HPA) axis is commonly
dysregulated in stress-related psychiatric disorders. Annexin A1 (ANXA1), an endogenous …

Disruptive physiology: olfaction and the microbiome–gut–brain axis

J Bienenstock, WA Kunze, P Forsythe - Biological Reviews, 2018 - Wiley Online Library
This review covers the field of olfaction and chemosensation of odorants and puts this
information into the context of interactions between microbes and behaviour; the microbiome …

[HTML][HTML] Chemotactic ligands that activate G-protein-coupled formylpeptide receptors

SA Krepel, JM Wang - International Journal of Molecular Sciences, 2019 - mdpi.com
Leukocyte infiltration is a hallmark of inflammatory responses. This process depends on the
bacterial and host tissue-derived chemotactic factors interacting with G-protein-coupled …

[HTML][HTML] Alcohol-drinking under limited-access procedures during mature adulthood accelerates the onset of cognitive impairment in mice

CL Jimenez Chavez, E Van Doren… - Frontiers in Behavioral …, 2022 - frontiersin.org
A history of heavy drinking increases vulnerability to, and the severity of, Alzheimer's
Disease (AD) and related dementias, with Alcohol Use Disorder (AUD) identified as the …

MAP kinases in regulation of NOX activity stimulated through two types of formyl peptide receptors in murine bone marrow granulocytes

Y Filina, A Gabdoulkhakova, A Rizvanov, V Safronova - Cellular signalling, 2022 - Elsevier
The functional activity of the phagocytes, as well as the development and resolution of the
inflammation, is determined by formylpeptide receptors (FPRs) signaling. There is a growing …