Animal models for screening anxiolytic-like drugs: a perspective
M Bourin - Dialogues in clinical neuroscience, 2015 - Taylor & Francis
Contemporary biological psychiatry uses experimental animal models to increase our
understanding of affective disorder pathogenesis. Modern anxiolytic drug discovery mainly …
understanding of affective disorder pathogenesis. Modern anxiolytic drug discovery mainly …
[HTML][HTML] Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology
K Tylek, E Trojan, M Regulska, E Lacivita… - Pharmacological …, 2021 - Springer
Formyl peptide receptors (FPRs) belong to the family of seven-transmembrane G protein-
coupled receptors. Among them, FPR2 is a low affinity receptor for N-formyl peptides and is …
coupled receptors. Among them, FPR2 is a low affinity receptor for N-formyl peptides and is …
[HTML][HTML] Placental endocrine function shapes cerebellar development and social behavior
CM Vacher, H Lacaille, JJ O'Reilly, J Salzbank… - Nature …, 2021 - nature.com
Compromised placental function or premature loss has been linked to diverse
neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a …
neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a …
Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes
Microglial activation plays a central role in poststroke inflammation and causes secondary
neuronal damage; however, it also contributes in debris clearance and chronic recovery …
neuronal damage; however, it also contributes in debris clearance and chronic recovery …
[HTML][HTML] Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression …
Abstract Tiagabine (Tia), a new-generation antiseizure drug that mimics the GABAergic
signaling by inhibiting GABA transporter type-1, is the least studied molecule in chronic …
signaling by inhibiting GABA transporter type-1, is the least studied molecule in chronic …
The role of annexin A1 and formyl peptide receptor 2/3 signaling in chronic corticosterone-induced depression-like behaviors and impairment in hippocampal …
AF Peritore, R Crupi, M Scuto… - CNS & Neurological …, 2020 - ingentaconnect.com
Background: The activity of the Hypothalamic-Pituitary-Adrenal (HPA) axis is commonly
dysregulated in stress-related psychiatric disorders. Annexin A1 (ANXA1), an endogenous …
dysregulated in stress-related psychiatric disorders. Annexin A1 (ANXA1), an endogenous …
Disruptive physiology: olfaction and the microbiome–gut–brain axis
J Bienenstock, WA Kunze, P Forsythe - Biological Reviews, 2018 - Wiley Online Library
This review covers the field of olfaction and chemosensation of odorants and puts this
information into the context of interactions between microbes and behaviour; the microbiome …
information into the context of interactions between microbes and behaviour; the microbiome …
[HTML][HTML] Chemotactic ligands that activate G-protein-coupled formylpeptide receptors
SA Krepel, JM Wang - International Journal of Molecular Sciences, 2019 - mdpi.com
Leukocyte infiltration is a hallmark of inflammatory responses. This process depends on the
bacterial and host tissue-derived chemotactic factors interacting with G-protein-coupled …
bacterial and host tissue-derived chemotactic factors interacting with G-protein-coupled …
[HTML][HTML] Alcohol-drinking under limited-access procedures during mature adulthood accelerates the onset of cognitive impairment in mice
CL Jimenez Chavez, E Van Doren… - Frontiers in Behavioral …, 2022 - frontiersin.org
A history of heavy drinking increases vulnerability to, and the severity of, Alzheimer's
Disease (AD) and related dementias, with Alcohol Use Disorder (AUD) identified as the …
Disease (AD) and related dementias, with Alcohol Use Disorder (AUD) identified as the …
MAP kinases in regulation of NOX activity stimulated through two types of formyl peptide receptors in murine bone marrow granulocytes
Y Filina, A Gabdoulkhakova, A Rizvanov, V Safronova - Cellular signalling, 2022 - Elsevier
The functional activity of the phagocytes, as well as the development and resolution of the
inflammation, is determined by formylpeptide receptors (FPRs) signaling. There is a growing …
inflammation, is determined by formylpeptide receptors (FPRs) signaling. There is a growing …