The current clinical solutions, including mechanical and bioprosthetic valves for valvular
heart diseases, are plagued by coagulation, calcification, nondurability, and the inability to …

Biofabrication is potentially an inherently sustainable manufacturing process of bio-hybrid
systems based on biomaterials embedded with cell communities. These bio-hybrids promise …

Despite the efforts devoted to drug discovery and development, the number of new drug
approvals have been decreasing. Specifically, cardiovascular developments have been …

In vitro cardiac modeling has taken great strides in the past decade. While most cell and
engineered tissue models have focused on cell and tissue contractile function as readouts …

Techniques to provide in vitro tissue culture have undergone significant changes during the
last decades, and current applications involve interactions of cells and organoids, three …

In recent years, the mathematical and computational sciences have developed novel
methodologies and insights that can aid in designing advanced bioreactors, microfluidic …

Tissue growth and remodeling (G&R) is often central to disease etiology and progression, so
understanding G&R is essential for understanding disease and developing effective …

Today's living world is enriched with a myriad of natural biological designs, shaped by
billions of years of evolution. Unraveling the construction rules of living organisms offers the …

A wide array of biomaterials are being developed to be used as tissue engineering
scaffolds, including metals, ceramics, polymers, and composites. For all biomaterials, the …

Healing in soft biological tissues is a chain of events on different time and length scales. This
work presents a computational framework to capture and couple important mechanical …