Background Genetic alterations of somatic cells can drive non-malignant clone formation
and promote cancer initiation. However, the link between these processes remains unclear …

Studies over the past three years have substantially expanded the involvements of
eukaryotic initiation factor 3 (eIF3) in messenger RNA (mRNA) translation. It now appears …

Background and aims Acute ST-Segment Myocardial infarction (STEMI) is a common
cardiovascular issue with a considerable burden of the disease. The underlying genetic …

Components of the translation apparatus, including ribosomal proteins, have been found in
cell nuclei in various organisms. Components of the translation apparatus are involved in …

A wide spectrum of genetic and epigenetic variations together with environmental factors
has made colorectal cancer (CRC), which involves the colon and rectum, a challenging and …

Inherited and somatic rare diseases result from> 200,000 genetic variants leading to loss-or
gain-of-toxic function, often caused by protein misfolding. Many of these misfolded variants …

Intrinsic resistance to current therapies, leading to dismal clinical outcomes, is a hallmark of
glioblastoma multiforme (GBM), the most common and aggressive brain tumor …

Altered expression of the translation factor eIF3e is associated with breast cancer
occurrence. We have previously shown that eIF3e deficiency leads to an impaired DNA …

Abstract eIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA
translation from initiation to termination, but mRNA‐selective functions of individual subunits …

Aging is associated with hypertension and brain blood flow dysregulation, which are major
risk factors for cardiovascular and neurodegenerative diseases. Structural remodeling …