Osteoporosis is one of the major bone disorders that affects both women and men, and
causes bone deterioration and bone strength. Bone remodeling maintains bone mass and …

Bone homeostasis is preserved by the balance of maintaining between the activity of
osteogenesis and osteoclastogenesis. However, investigations for the osteoclastogenesis …

Biodegradable polymers have been used with various systems for tissue engineering.
Among them, poly (lactic-co-glycolic) acid (PLGA) has been widely used as a biomaterial for …

Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B receptor
(TrkB) are expressed in human osteoblasts and mediate fracture healing. BDNF/TrkB …

Currently, healing of large bone defects faces significant challenges such as a bulk of bone
regeneration and revascularization on the bone defect region. Here, a “cell-free scaffold …

Traditional bone replacement materials have been developed with the goal of directing the
osteogenesis of osteoblastic cell lines toward differentiation and therefore achieving …

Insulin-like growth factor (IGF)-1 is a polypeptide hormone with vital biological functions in
bone cells. The abnormal expression of IGF-1 has a serious effect on bone growth …

The present study evaluated the in vitro effect of metformin (Met) and total flavonoids of
Rhizoma Drynariae (TFRD) on osteoclasts, osteocytes, and osteoblasts at different stages …

In the ageing skeleton, the balance of bone reconstruction could commonly be broken by the
increasing of bone resorption and decreasing of bone formation. Consequently, the bone …

Tumor bone metastasis is still difficult to cure despite the development of various treatment
strategies. Drug delivery systems can improve the poor biological distribution of anticancer …