Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation

RJ Mead, N Shan, HJ Reiser, F Marshall… - Nature Reviews Drug …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis

H Ilieva, M Vullaganti, J Kwan - bmj, 2023 - bmj.com
Although the past two decades have produced exciting discoveries in the genetics and
pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy …

At-home wearables and machine learning sensitively capture disease progression in amyotrophic lateral sclerosis

AS Gupta, S Patel, A Premasiri, F Vieira - Nature Communications, 2023 - nature.com
Amyotrophic lateral sclerosis causes degeneration of motor neurons, resulting in
progressive muscle weakness and impairment in motor function. Promising drug …

Wearable device and smartphone data quantify ALS progression and may provide novel outcome measures

SA Johnson, M Karas, KM Burke, M Straczkiewicz… - NPJ Digital …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) therapeutic development has largely relied on staff-
administered functional rating scales to determine treatment efficacy. We sought to …

ALSFRS-R-SE: an adapted, annotated, and self-explanatory version of the revised amyotrophic lateral sclerosis functional rating scale

A Maier, M Boentert, P Reilich, S Witzel, S Petri… - … research and practice, 2022 - Springer
Abstract Background The ALS Functional Rating Scale in its revised version (ALSFRS-R) is
a disease-specific severity score that reflects motor impairment and functional deterioration …

A systematic review and narrative analysis of digital speech biomarkers in Motor Neuron Disease

M Bowden, E Beswick, J Tam, D Perry, A Smith… - NPJ digital …, 2023 - nature.com
Abstract Motor Neuron Disease (MND) is a progressive and largely fatal neurodegeneritve
disorder with a lifetime risk of approximately 1 in 300. At diagnosis, up to 25% of people with …

[HTML][HTML] A road map for remote digital health technology for motor neuron disease

RPA van Eijk, A Beelen, ET Kruitwagen… - Journal of Medical …, 2021 - jmir.org
Despite recent and potent technological advances, the real-world implementation of remote
digital health technology in the care and monitoring of patients with motor neuron disease …

A systematic review of digital technology to evaluate motor function and disease progression in motor neuron disease

E Beswick, T Fawcett, Z Hassan, D Forbes, R Dakin… - Journal of …, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is the most common subtype of motor neuron disease
(MND). The current gold-standard measure of progression is the ALS Functional Rating …

[HTML][HTML] Considerations for amyotrophic lateral sclerosis (ALS) clinical trial design

CN Fournier - Neurotherapeutics, 2022 - Elsevier
Thoughtful clinical trial design is critical for efficient therapeutic development, particularly in
the field of amyotrophic lateral sclerosis (ALS), where trials often aim to detect modest …

Remote digital assessment of amyotrophic lateral sclerosis functional rating scale–a multicenter observational study

T Meyer, S Spittel, T Grehl, U Weyen… - … Lateral Sclerosis and …, 2023 - Taylor & Francis
Objective Remote self-assessment of the revised amyotrophic lateral sclerosis functional
rating scale (ALSFRS-R) using digital data capture was investigated for its feasibility as an …