Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Although the past two decades have produced exciting discoveries in the genetics and
pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy …

Amyotrophic lateral sclerosis causes degeneration of motor neurons, resulting in
progressive muscle weakness and impairment in motor function. Promising drug …

Amyotrophic lateral sclerosis (ALS) therapeutic development has largely relied on staff-
administered functional rating scales to determine treatment efficacy. We sought to …

Abstract Background The ALS Functional Rating Scale in its revised version (ALSFRS-R) is
a disease-specific severity score that reflects motor impairment and functional deterioration …

Abstract Motor Neuron Disease (MND) is a progressive and largely fatal neurodegeneritve
disorder with a lifetime risk of approximately 1 in 300. At diagnosis, up to 25% of people with …

Despite recent and potent technological advances, the real-world implementation of remote
digital health technology in the care and monitoring of patients with motor neuron disease …

Amyotrophic lateral sclerosis (ALS) is the most common subtype of motor neuron disease
(MND). The current gold-standard measure of progression is the ALS Functional Rating …

Thoughtful clinical trial design is critical for efficient therapeutic development, particularly in
the field of amyotrophic lateral sclerosis (ALS), where trials often aim to detect modest …

Objective Remote self-assessment of the revised amyotrophic lateral sclerosis functional
rating scale (ALSFRS-R) using digital data capture was investigated for its feasibility as an …