Functional heterogeneity within rat orbitofrontal cortex in reward learning and decision making

A Izquierdo - Journal of Neuroscience, 2017 - Soc Neuroscience
Rat orbitofrontal cortex (OFC) is located in the dorsal bank of the rhinal sulcus, and is
divided into the medial orbital area, ventral orbital area, ventrolateral orbital area, lateral …

A roadmap to integrate astrocytes into Systems Neuroscience

KV Kastanenka, R Moreno‐Bote, M De Pittà, G Perea… - Glia, 2020 - Wiley Online Library
Abstract Systems neuroscience is still mainly a neuronal field, despite the plethora of
evidence supporting the fact that astrocytes modulate local neural circuits, networks, and …

Posterior parietal cortex represents sensory history and mediates its effects on behaviour

A Akrami, CD Kopec, ME Diamond, CD Brody - Nature, 2018 - nature.com
Many models of cognition and of neural computations posit the use and estimation of prior
stimulus statistics,,,: it has long been known that working memory and perception are …

Sequential replay of nonspatial task states in the human hippocampus

NW Schuck, Y Niv - Science, 2019 - science.org
INTRODUCTION The hippocampus plays an important role in memory and spatial
navigation. When rodents navigate a spatial maze, hippocampal neurons called place cells …

Evolving schema representations in orbitofrontal ensembles during learning

J Zhou, C Jia, M Montesinos-Cartagena, MPH Gardner… - Nature, 2021 - nature.com
How do we learn about what to learn about? Specifically, how do the neural elements in our
brain generalize what has been learned in one situation to recognize the common structure …

Direct electrical stimulation of lateral orbitofrontal cortex acutely improves mood in individuals with symptoms of depression

VR Rao, KK Sellers, DL Wallace, MB Lee… - Current Biology, 2018 - cell.com
Mood disorders cause significant morbidity and mortality, and existing therapies fail 20%–
30% of patients. Deep brain stimulation (DBS) is an emerging treatment for refractory mood …

Orbitofrontal circuits control multiple reinforcement-learning processes

SM Groman, C Keistler, AJ Keip, E Hammarlund… - Neuron, 2019 - cell.com
Adaptive decision making in dynamic environments requires multiple reinforcement-learning
steps that may be implemented by dissociable neural circuits. Here, we used a novel …

Role of anterior cingulate cortex inputs to periaqueductal gray for pain avoidance

JY Lee, T You, CH Lee, GH Im, H Seo, CW Woo… - Current Biology, 2022 - cell.com
Although pain-related excessive fear is known to be a key factor in chronic pain disability,
which involves the anterior cingulate cortex (ACC), little is known about the downstream …

Sensorimotor strategies and neuronal representations for shape discrimination

CC Rodgers, R Nogueira, BC Pil, EA Greeman… - Neuron, 2021 - cell.com
Humans and other animals can identify objects by active touch, requiring the coordination of
exploratory motion and tactile sensation. Both the motor strategies and neural …

The geometry of cortical representations of touch in rodents

R Nogueira, CC Rodgers, RM Bruno, S Fusi - Nature Neuroscience, 2023 - nature.com
Neurons often encode highly heterogeneous non-linear functions of multiple task variables,
a signature of a high-dimensional geometry. We studied the representational geometry in …