In recent years, a tremendous effort has been devoted to the detailed characterization of the
phenotype and function of distinct T cell subpopulations in humans, as well as to their …

Natural killer (NK) cell‐mediated cytotoxicity is governed by the formation of a lytic immune
synapse in discrete regulated steps, which give rise to an extensive array of cellular …

Many immune correlates of CD8+ T-cell-mediated control of HIV replication, including
polyfunctionality, proliferative ability, and inhibitory receptor expression, have been …

Cytolytic CD8 T cells play a crucial role in the control and elimination of virus-infected cells
and are a major focus of HIV cure efforts. However, it has been shown that HIV-specific CD8 …

Background & aims Mortality resulting from influenza (flu) virus infections occurs primarily in
the elderly through declining immunity. Studies in mice have suggested beneficial effects of …

Secretory lysosomes of natural killer (NK) cells, containing perforin and granzymes, are
indispensable for NK-cell cytotoxicity because their release results in the induction of target …

Influenza vaccines remain the most effective tools to prevent flu and its complications.
Trivalent or quadrivalent inactivated influenza vaccines primarily elicit antibodies towards …

Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyperinflammatory
syndrome with prolonged high fever, hepatosplenomegaly and characteristic laboratory …

Recent data suggest that CD8+ T-cell effector activity is an important component in the
control of HIV replication in elite controllers (ECs). One critical element of CD8+ T-cell …

Familial hemophagocytic lymphohistiocytosis (FHL) is an inherited, often fatal immune
deficiency characterized by severe systemic hyperinflammation. Although allogeneic bone …