Phenotype and function of human T lymphocyte subsets: consensus and issues
V Appay, RAW van Lier, F Sallusto… - Cytometry Part …, 2008 - Wiley Online Library
In recent years, a tremendous effort has been devoted to the detailed characterization of the
phenotype and function of distinct T cell subpopulations in humans, as well as to their …
phenotype and function of distinct T cell subpopulations in humans, as well as to their …
Cell biological steps and checkpoints in accessing NK cell cytotoxicity
Natural killer (NK) cell‐mediated cytotoxicity is governed by the formation of a lytic immune
synapse in discrete regulated steps, which give rise to an extensive array of cellular …
synapse in discrete regulated steps, which give rise to an extensive array of cellular …
[HTML][HTML] Perforin Expression Directly Ex Vivo by HIV-Specific CD8+ T-Cells Is a Correlate of HIV Elite Control
Many immune correlates of CD8+ T-cell-mediated control of HIV replication, including
polyfunctionality, proliferative ability, and inhibitory receptor expression, have been …
polyfunctionality, proliferative ability, and inhibitory receptor expression, have been …
Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies
C Petrovas, S Ferrando-Martinez, MY Gerner… - Science translational …, 2017 - science.org
Cytolytic CD8 T cells play a crucial role in the control and elimination of virus-infected cells
and are a major focus of HIV cure efforts. However, it has been shown that HIV-specific CD8 …
and are a major focus of HIV cure efforts. However, it has been shown that HIV-specific CD8 …
[HTML][HTML] Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults
K Ivory, E Prieto, C Spinks, CN Armah, AJ Goldson… - Clinical Nutrition, 2017 - Elsevier
Background & aims Mortality resulting from influenza (flu) virus infections occurs primarily in
the elderly through declining immunity. Studies in mice have suggested beneficial effects of …
the elderly through declining immunity. Studies in mice have suggested beneficial effects of …
LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity
K Krzewski, A Gil-Krzewska, V Nguyen… - Blood, The Journal …, 2013 - ashpublications.org
Secretory lysosomes of natural killer (NK) cells, containing perforin and granzymes, are
indispensable for NK-cell cytotoxicity because their release results in the induction of target …
indispensable for NK-cell cytotoxicity because their release results in the induction of target …
[HTML][HTML] The role of cell-mediated immunity against influenza and its implications for vaccine evaluation
Y Janssens, J Joye, G Waerlop, F Clement… - Frontiers in …, 2022 - frontiersin.org
Influenza vaccines remain the most effective tools to prevent flu and its complications.
Trivalent or quadrivalent inactivated influenza vaccines primarily elicit antibodies towards …
Trivalent or quadrivalent inactivated influenza vaccines primarily elicit antibodies towards …
Primary and secondary hemophagocytic lymphohistiocytosis: clinical features, pathogenesis and therapy
S Gupta, S Weitzman - Expert review of clinical immunology, 2010 - Taylor & Francis
Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyperinflammatory
syndrome with prolonged high fever, hepatosplenomegaly and characteristic laboratory …
syndrome with prolonged high fever, hepatosplenomegaly and characteristic laboratory …
Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression
AR Hersperger, JN Martin, LY Shin… - Blood, The Journal …, 2011 - ashpublications.org
Recent data suggest that CD8+ T-cell effector activity is an important component in the
control of HIV replication in elite controllers (ECs). One critical element of CD8+ T-cell …
control of HIV replication in elite controllers (ECs). One critical element of CD8+ T-cell …
Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis
X Li, T Wirtz, T Weber, M Lebedin, ED Lowenstein… - Science …, 2024 - science.org
Familial hemophagocytic lymphohistiocytosis (FHL) is an inherited, often fatal immune
deficiency characterized by severe systemic hyperinflammation. Although allogeneic bone …
deficiency characterized by severe systemic hyperinflammation. Although allogeneic bone …