Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

Post COVID-19 syndrome in patients with asymptomatic/mild form

A Malkova, I Kudryavtsev, A Starshinova, D Kudlay… - Pathogens, 2021 - mdpi.com
Post COVID-19 Syndrome (PCS) is a complex of various symptoms developing a month or
more after the acute phase of the disease. The cases of PCS development among patients …

Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study

M Augustin, P Schommers, M Stecher… - The Lancet Regional …, 2021 - thelancet.com
Background While the leading symptoms during coronavirus disease 2019 (COVID-19) are
acute and the majority of patients fully recover, a significant fraction of patients now …

COVID-19 neuropathology at columbia university irving medical center/New York presbyterian hospital

KT Thakur, EH Miller, MD Glendinning, O Al-Dalahmah… - Brain, 2021 - academic.oup.com
Many patients with SARS-CoV-2 infection develop neurological signs and symptoms;
although, to date, little evidence exists that primary infection of the brain is a significant …

Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”

EL Graham, JR Clark, ZS Orban, PH Lim… - Annals of clinical …, 2021 - Wiley Online Library
Abstract Objective Most SARS‐CoV‐2‐infected individuals never require hospitalization.
However, some develop prolonged symptoms. We sought to characterize the spectrum of …

[HTML][HTML] Challenges in defining Long COVID: Striking differences across literature, Electronic Health Records, and patient-reported information

HM Rando, TD Bennett, JB Byrd, C Bramante… - MedRxiv, 2021 - ncbi.nlm.nih.gov
Since late 2019, the novel coronavirus SARS-CoV-2 has introduced a wide array of health
challenges globally. In addition to a complex acute presentation that can affect multiple …

[HTML][HTML] Post-COVID syndrome

M Hallek, K Adorjan, U Behrends, G Ertl… - Deutsches Ärzteblatt …, 2023 - ncbi.nlm.nih.gov
Background As defined by the WHO, the term post-COVID syndrome (PCS) embraces a
group of symptoms that can occur following the acute phase of a SARS-CoV-2 infection and …

Neuropathological findings from COVID‐19 patients with neurological symptoms argue against a direct brain invasion of SARS‐CoV‐2: A critical systematic review

G Cosentino, M Todisco, N Hota… - European journal of …, 2021 - Wiley Online Library
Background and purpose Neuropathological studies can elucidate the mechanisms of
nervous system damage associated with SARS‐CoV‐2 infection. Despite literature on this …

SARS-CoV-2 involvement in central nervous system tissue damage

MA Haidar, Z Shakkour, MA Reslan… - Neural Regeneration …, 2022 - journals.lww.com
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread
globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the …

Inflammatory mediators of platelet activation: focus on atherosclerosis and COVID-19

P Theofilis, M Sagris, AS Antonopoulos… - International Journal of …, 2021 - mdpi.com
Background: Atherosclerotic cardiovascular diseases are characterized by a dysregulated
inflammatory and thrombotic state, leading to devastating complications with increased …