Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

K elch‐like ECH‐associated protein 1 (K eap1)‐nuclear factor erythroid 2‐related factor 2 (N
rf2)‐antioxidant response elements (ARE) pathway represents one of the most important …

The Kelch-like ECH associated protein 1 (Keap1) is a component of a Cullin3-based Cullin-
RING E3 ubiquitin ligase (CRL) multisubunit protein complex. Within the CRL, homodimeric …

An elaborate network of highly inducible proteins protects aerobic cells against the
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …

The transcription factor NF-E2 p45-related factor 2 (Nrf2), a master regulator of
cytoprotective genes, is controlled by dimeric Kelch-like ECH associated protein 1 (Keap1) …

Cruciferous vegetables hold a myriad of bioactive molecules that are renowned for
possessing unique medicinal benefits. Sulforaphane (SFN) is one of the potential …

NRF2 (nuclear factor erythroid 2-related factor 2) is a critical regulator of the cellular stress
response. It is a transcription factor that controls the expression of hundreds of genes. We …

Cardiovascular disease (CVD) causes an unparalleled proportion of the global burden of
disease and will remain the main cause of mortality for the near future. Oxidative stress plays …

Natural products have always been exploited to promote health and served as a valuable
source for the discovery of new drugs. In this review, the great potential of natural …

Living organisms are endowed with the capability to tackle various forms of cellular stress
due to the presence of molecular chaperone machinery complexes that are ubiquitous …