Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures

V Crunelli, ML Lőrincz, C McCafferty, RC Lambert… - Brain, 2020 - academic.oup.com
Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …

Large scale brain models of epilepsy: dynamics meets connectomics

MP Richardson - Journal of Neurology, Neurosurgery & Psychiatry, 2012 - jnnp.bmj.com
The brain is in a constant state of dynamic change, for example switching between cognitive
and behavioural tasks, and between wakefulness and sleep. The brains of people with …

Altered functional–structural coupling of large-scale brain networks in idiopathic generalized epilepsy

Z Zhang, W Liao, H Chen, D Mantini, JR Ding, Q Xu… - Brain, 2011 - academic.oup.com
The human brain is a large-scale integrated network in the functional and structural domain.
Graph theoretical analysis provides a novel framework for analysing such complex …

Identifying neural drivers with functional MRI: an electrophysiological validation

O David, I Guillemain, S Saillet, S Reyt… - PLoS …, 2008 - journals.plos.org
Whether functional magnetic resonance imaging (fMRI) allows the identification of neural
drivers remains an open question of particular importance to refine physiological and …

Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain

J Gotman, C Grova, A Bagshaw… - Proceedings of the …, 2005 - National Acad Sciences
Our objective was to evaluate the brain regions showing increased and decreased
metabolism in patients at the time of generalized bursts of epileptic discharges in order to …

Frontal theta EEG activity correlates negatively with the default mode network in resting state

R Scheeringa, MCM Bastiaansen, KM Petersson… - International journal of …, 2008 - Elsevier
We used simultaneously recorded EEG and fMRI to investigate in which areas the BOLD
signal correlates with frontal theta power changes, while subjects were quietly lying resting …

Cellular and network mechanisms of spike‐wave seizures

H Blumenfeld - Epilepsia, 2005 - Wiley Online Library
Spike‐wave seizures are often considered a relatively “pure” form of epilepsy, with a uniform
defect present in all patients and involvement of the whole brain homogenously. Here, we …

Cortical and subcortical networks in human secondarily generalized tonic–clonic seizures

H Blumenfeld, GI Varghese, MJ Purcaro, JE Motelow… - Brain, 2009 - academic.oup.com
Generalized tonic–clonic seizures are among the most dramatic physiological events in the
nervous system. The brain regions involved during partial seizures with secondary …

Network connectivity in epilepsy: resting state fMRI and EEG–fMRI contributions

M Centeno, DW Carmichael - Frontiers in neurology, 2014 - frontiersin.org
There is a growing body of evidence pointing toward large-scale networks underlying the
core phenomena in epilepsy, from seizure generation to cognitive dysfunction or response …

Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging

X Bai, M Vestal, R Berman, M Negishi… - Journal of …, 2010 - Soc Neuroscience
Absence seizures are 5–10 s episodes of impaired consciousness accompanied by 3–4 Hz
generalized spike-and-wave discharge on electroencephalography (EEG). The time course …