Ebola virus disease

ST Jacob, I Crozier, WA Fischer, A Hewlett… - Nature reviews Disease …, 2020 - nature.com
Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …

The pathogenesis of Ebola virus disease

L Baseler, DS Chertow, KM Johnson… - Annual Review of …, 2017 - annualreviews.org
For almost 50 years, ebolaviruses and related filoviruses have been repeatedly reemerging
across the vast equatorial belt of the African continent to cause epidemics of highly fatal …

[HTML][HTML] Lactate is a natural suppressor of RLR signaling by targeting MAVS

W Zhang, G Wang, ZG Xu, H Tu, F Hu, J Dai, Y Chang… - Cell, 2019 - cell.com
Summary RLR-mediated type I IFN production plays a pivotal role in elevating host immunity
for viral clearance and cancer immune surveillance. Here, we report that glycolysis, which is …

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

TK Warren, R Jordan, MK Lo, AS Ray, RL Mackman… - Nature, 2016 - nature.com
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the
number of cases and fatalities, geographic distribution, and number of nations affected …

A randomized, controlled trial of ZMapp for Ebola virus infection

Prevail II Writing Group - New England Journal of Medicine, 2016 - Mass Medical Soc
Background Data from studies in nonhuman primates suggest that the triple monoclonal
antibody cocktail ZMapp is a promising immune-based treatment for Ebola virus disease …

Ebola virus disease

D Malvy, AK McElroy, H de Clerck, S Günther… - The Lancet, 2019 - thelancet.com
Ebolaviruses are pathogenic agents associated with a severe, potentially fatal, systemic
disease in man and great apes. Four species of ebolaviruses have been identified in west or …

Clinical management of Ebola virus disease in the United States and Europe

TM Uyeki, AK Mehta, RT Davey Jr… - … England Journal of …, 2016 - Mass Medical Soc
Background Available data on the characteristics of patients with Ebola virus disease (EVD)
and clinical management of EVD in settings outside West Africa, as well as the …

[HTML][HTML] Cytokine-like roles for metabolites in immunity

Z Zasłona, LAJ O'Neill - Molecular cell, 2020 - cell.com
Metabolites have functions in the immune system independent of their conventional roles as
sources or intermediates in biosynthesis and bioenergetics. We are still in the pioneering …

Diagnosis of Ebola virus disease: past, present, and future

MJ Broadhurst, TJG Brooks… - Clinical microbiology …, 2016 - Am Soc Microbiol
Laboratory diagnosis of Ebola virus disease plays a critical role in outbreak response efforts;
however, establishing safe and expeditious testing strategies for this high-biosafety-level …

Experimental treatment with favipiravir for Ebola virus disease (the JIKI Trial): a historically controlled, single-arm proof-of-concept trial in Guinea

D Sissoko, C Laouenan, E Folkesson… - PLoS …, 2016 - journals.plos.org
Background Ebola virus disease (EVD) is a highly lethal condition for which no specific
treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak …