Ebola virus disease
ST Jacob, I Crozier, WA Fischer, A Hewlett… - Nature reviews Disease …, 2020 - nature.com
Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …
The pathogenesis of Ebola virus disease
L Baseler, DS Chertow, KM Johnson… - Annual Review of …, 2017 - annualreviews.org
For almost 50 years, ebolaviruses and related filoviruses have been repeatedly reemerging
across the vast equatorial belt of the African continent to cause epidemics of highly fatal …
across the vast equatorial belt of the African continent to cause epidemics of highly fatal …
[HTML][HTML] Lactate is a natural suppressor of RLR signaling by targeting MAVS
W Zhang, G Wang, ZG Xu, H Tu, F Hu, J Dai, Y Chang… - Cell, 2019 - cell.com
Summary RLR-mediated type I IFN production plays a pivotal role in elevating host immunity
for viral clearance and cancer immune surveillance. Here, we report that glycolysis, which is …
for viral clearance and cancer immune surveillance. Here, we report that glycolysis, which is …
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the
number of cases and fatalities, geographic distribution, and number of nations affected …
number of cases and fatalities, geographic distribution, and number of nations affected …
A randomized, controlled trial of ZMapp for Ebola virus infection
Prevail II Writing Group - New England Journal of Medicine, 2016 - Mass Medical Soc
Background Data from studies in nonhuman primates suggest that the triple monoclonal
antibody cocktail ZMapp is a promising immune-based treatment for Ebola virus disease …
antibody cocktail ZMapp is a promising immune-based treatment for Ebola virus disease …
Ebola virus disease
D Malvy, AK McElroy, H de Clerck, S Günther… - The Lancet, 2019 - thelancet.com
Ebolaviruses are pathogenic agents associated with a severe, potentially fatal, systemic
disease in man and great apes. Four species of ebolaviruses have been identified in west or …
disease in man and great apes. Four species of ebolaviruses have been identified in west or …
Clinical management of Ebola virus disease in the United States and Europe
TM Uyeki, AK Mehta, RT Davey Jr… - … England Journal of …, 2016 - Mass Medical Soc
Background Available data on the characteristics of patients with Ebola virus disease (EVD)
and clinical management of EVD in settings outside West Africa, as well as the …
and clinical management of EVD in settings outside West Africa, as well as the …
[HTML][HTML] Cytokine-like roles for metabolites in immunity
Z Zasłona, LAJ O'Neill - Molecular cell, 2020 - cell.com
Metabolites have functions in the immune system independent of their conventional roles as
sources or intermediates in biosynthesis and bioenergetics. We are still in the pioneering …
sources or intermediates in biosynthesis and bioenergetics. We are still in the pioneering …
Diagnosis of Ebola virus disease: past, present, and future
MJ Broadhurst, TJG Brooks… - Clinical microbiology …, 2016 - Am Soc Microbiol
Laboratory diagnosis of Ebola virus disease plays a critical role in outbreak response efforts;
however, establishing safe and expeditious testing strategies for this high-biosafety-level …
however, establishing safe and expeditious testing strategies for this high-biosafety-level …
Experimental treatment with favipiravir for Ebola virus disease (the JIKI Trial): a historically controlled, single-arm proof-of-concept trial in Guinea
D Sissoko, C Laouenan, E Folkesson… - PLoS …, 2016 - journals.plos.org
Background Ebola virus disease (EVD) is a highly lethal condition for which no specific
treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak …
treatment has proven efficacy. In September 2014, while the Ebola outbreak was at its peak …