The diversity of RNA structural elements and their documented role in human diseases
make RNA an attractive therapeutic target. However, progress in drug discovery and …

In low-income populations, neglected diseases are the principal cause of mortality. Of these,
leishmaniasis and malaria, being parasitic, protozoan infections, affect millions of people …

In silico prediction of antileishmanial activity using quantitative structure–activity relationship
(QSAR) models has been developed on limited and small datasets. Nowadays, the …

Nitrobenzothiazinones (BTZs) are a very potent class of antibiotics against Mycobacterium
tuberculosis. However, relationships between their structural properties and whole cell …

Chagas is a neglected tropical disease caused by the parasite Trypanosoma cruzi with no
effective treatment in all its forms. There is a need to find more effective therapeutic …

Leishmaniasis, a parasitic disease that represents a threat to the life of millions of people
around the globe, is currently lacking effective treatments. We have previously reported on …

Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without
efficient treatment for chronic patients. Despite the efforts, no new drugs have been …

Leishmaniasis is a complex disease; it is classified under neglected diseases and it causes
significant health problems in many developing countries. Even though some drugs are …

In recent years, blocking the interaction of programmed cell death receptor‐1 (PD‐1) and
programmed cell death ligand‐1 (PD‐L1) has been recognized as one of the promising …

Search for new antiviral medications has surged in the past two years due to the COVID-19
crisis. Toll-like receptor 7 (TLR7) is among one of the most important TLR proteins of innate …