Oxidative stress is an important pathomechanism found in numerous ocular degenerative
diseases. To provide a better understanding of the mechanism and treatment of …

Mitochondrial dysfunction increases reactive oxygen species (ROS) production and when
this overwhelms the cellular antioxidant defences, oxidative stress ensues. Oxidative stress …

Current evidence suggests lutein and its isomers play important roles in ocular development
in utero and throughout the life span, in vision performance in young and later adulthood …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Background Oxidative stress contributes to retina ganglion cells (RGCs) loss in variety of
ocular diseases, including ocular trauma, ocular vein occlusion, and glaucoma. Scavenging …

Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy
triggered by both environmental and genetic risk factors. Several ocular tissues, including …

The exact mechanism of retinal ganglion cell loss in the pathogenesis of glaucoma is yet to
be understood. Mitochondrial damage‐associated molecular patterns (DAMPs) resulting …

Glaucoma, a leading cause of irreversible blindness worldwide, is an optic neuropathy
characterized by the progressive death of retinal ganglion cells (RGCs). Elevated intraocular …

Retinoic acid (RA), the derivative of vitamin A/retinol, is a signaling molecule with important
implications in health and disease. It is a well-known developmental morphogen that …

Primary open-angle glaucoma (POAG) is a common form of glaucoma in which retinal
ganglion cells (RGCs) die at varying intervals. Primary open-angle glaucoma is often …