Positive pressure ventilation (PPV) causes a radical departure from the physiology of
spontaneous breathing where a positive intrathoracic pressure is only generated transiently …

Background Recent analyses of patient data in acute respiratory distress syndrome (ARDS)
showed that a lower ventilator driving pressure was associated with reduced relative risk of …

Computer simulation offers a fresh approach to traditional medical research that is
particularly well suited to investigating issues related to mechanical ventilation. Patients …

Background Apnoeic oxygenation can come close to matching the oxygen demands of the
apnoeic patient but does not facilitate carbon dioxide (CO 2) elimination, potentially resulting …

Background Clinical trials have, so far, failed to establish clear beneficial outcomes of
recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome …

Background. Positive end-expiratory pressure (PEEP) is widely used to improve
oxygenation and prevent alveolar collapse in mechanically ventilated patients with the acute …

Objective We aimed to use a high-fidelity computational model that captures key interactions
between the cardiovascular and pulmonary systems to investigate whether current CPR …

Acute Respiratory Distress Syndrome (ARDS), also known as noncardiogenic pulmonary
edema, is a severe condition that affects around one in ten-thousand people every year with …

In this study, we used a high-fidelity integrated computational model of the respiratory and
cardiovascular systems to investigate cardiopulmonary resuscitation (CPR) after cardiac …

This paper presents the methodology used in patient-specific calibration of a novel highly
integrated model of the cardiovascular and pulmonary pathophysiology associated with …