The structure and function of biomolecules are strongly influenced by their hydration shells.
Structural fluctuations and molecular excitations of hydrating water molecules cover a broad …

Infrared (IR; or mid-infrared, MIR; 4000-400 cm− 1; 2500–25,000 nm) spectroscopy has
become one of the most powerful and versatile tools at the disposal of modern bioscience …

The reorientation and hydrogen-bond dynamics of water molecules within the hydration
shell of a B-DNA dodecamer, which are of interest for many of its biochemical functions, are …

Hydration water on the surface of a protein is thought to mediate the thermodynamics of
protein–ligand interactions. For hydration water to play a role beyond modulating global …

Many biological processes such as photosynthesis and signal transduction proceed at
lipid/water interfaces. Although water molecules inside lipid membranes are considered to …

Interfacial water in the vicinity of lipids plays an important role in many biological processes,
such as drug delivery, ion transportation, and lipid fusion. Hence, molecular‐level …

Sugars function as bioprotectants by stabilizing biomolecules during dehydration, thermal
stress, and freeze–thaw cycles. A buildup of sugars occurs in many organisms upon their …

Cells are extremely crowded, and a central question in biology is how this affects the
intracellular water. Here, we use ultrafast vibrational spectroscopy and dielectric-relaxation …

Determining the secondary and tertiary structures of proteins at aqueous interfaces is crucial
for understanding their function, but measuring these structures selectively at the interface is …

Two-dimensional infrared (2D IR) spectroscopy has recently emerged as a powerful tool
with applications in many areas of scientific research. The inherent high time resolution …