International AIDS Society global scientific strategy: towards an HIV cure 2016

SG Deeks, SR Lewin, AL Ross, J Ananworanich… - Nature medicine, 2016 - nature.com
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …

Applying the behavioural and social sciences research (BSSR) functional framework to HIV cure research

K Dubé, JD Auerbach, MJ Stirratt… - African Journal of …, 2019 - journals.lww.com
Introduction: The search for an HIV cure involves important behavioural and social
processes that complement the domains of biomedicine. However, the field has yet to tap …

Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessment

GE Henderson, HL Peay, E Kroon, RJ Cadigan… - Journal of medical …, 2018 - jme.bmj.com
Though antiretroviral therapy is the standard of care for people living with HIV, its treatment
limitations, burdens, stigma and costs lead to continued interest in HIV cure research. Early …

'Well, it's the risk of the unknown… right?': a qualitative study of perceived risks and benefits of HIV cure research in the United States

K Dubé, J Taylor, L Sylla, D Evans, L Dee, A Burton… - PloS one, 2017 - journals.plos.org
Introduction Biomedical research towards an HIV cure is advancing in the United States and
elsewhere, yet little is known about perceptions of risks and benefits among potential study …

Towards multidisciplinary HIV-cure research: integrating social science with biomedical research

CI Grossman, AL Ross, JD Auerbach… - Trends in …, 2016 - cell.com
The quest for a cure for HIV remains a timely and key challenge for the HIV research
community. Despite significant scientific advances, current HIV therapy regimens do not …

Stakeholder engagement in HIV cure research: lessons learned from other HIV interventions and the way forward

YR Lo, C Chu, J Ananworanich, JL Excler… - AIDS Patient Care and …, 2015 - liebertpub.com
Clinical and basic science advances have raised considerable hope for achieving an HIV
cure by accelerating research. This research is dominated primarily by issues about the …

Indirect benefits in HIV cure clinical research: A qualitative analysis

A Gilbertson, EP Kelly, S Rennie… - AIDS Research and …, 2019 - liebertpub.com
Currently, much of early phase HIV cure research involves unknown and potentially serious
risks, with little or no chance of direct health benefits. During informed consent, researchers …

In vivo models of human immunodeficiency virus persistence and cure strategies

CC Nixon, M Mavigner, G Silvestri… - The Journal of …, 2017 - academic.oup.com
Current HIV therapy is not curative regardless of how soon after infection it is initiated or how
long it is administered, and therapy interruption almost invariably results in robust viral …

Perceptions of equipoise, risk–benefit ratios, and “otherwise healthy volunteers” in the context of early-phase HIV cure research in the United States: a qualitative …

K Dubé, L Dee, D Evans, L Sylla… - Journal of Empirical …, 2018 - journals.sagepub.com
Early-phase HIV cure research is conducted against a background of highly effective
antiretroviral therapy, and involves risky interventions in individuals who enjoy an almost …

Patterns of patient and healthcare provider viewpoints regarding participation in HIV cure-related clinical trials. Findings from a multicentre French survey using Q …

C Protière, B Spire, M Mora, I Poizot-Martin, M Préau… - PLoS …, 2017 - journals.plos.org
Context Despite huge advances in the fight against HIV concerning diagnosis, clinical
efficacy of antiretroviral treatments (ART), patient survival and quality of life, there is still no …