Elementary flux modes (EFMs) emerged as a formal concept to describe metabolic
pathways and have become an established tool for constraint-based modeling and …

Production of chemicals in microorganisms is no longer restricted to products arising from
native metabolic potential. In this review, we highlight the evolution of metabolic engineering …

This book delivers a comprehensive and insightful account of applying mathematical
modelling approaches to very large biological systems and networks—a fundamental aspect …

Metabolic engineering of plants with enhanced crop yield and value-added compositional
traits is particularly challenging as they probably exhibit the highest metabolic network …

The flux distribution in metabolic network can be decomposed as non-negative linear
combinations of elementary flux modes (EFMs). Identifying biologically relevant EFM …

Background The leading edge of the global problem of antibiotic resistance necessitates
novel therapeutic strategies. This study develops a novel systems biology driven approach …

Bioleaching with organic acids is an option for recovery of rare earth elements (REE) and or
other valuable metals from consumer or industrial wastes. Biohydrometallurgy can play an …

Elementary flux modes (EFMs) are non‐decomposable steady‐state fluxes through
metabolic networks. Every possible flux through a network can be described as a …

Selecting appropriate metabolic engineering targets to build efficient cell factories
maximizing the bioconversion of industrial by-products to valuable compounds taking into …

The metabolic network of an organism can be analyzed as a constraint-based model. This
analysis can be biased, optimizing an objective such as growth rate, or unbiased, aiming to …