Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease

M Kumar, N Bansal - Molecular neurobiology, 2022 - Springer
Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration

S Fakhri, A Iranpanah, MM Gravandi, SZ Moradi… - Phytomedicine, 2021 - Elsevier
Background As common, progressive, and chronic causes of disability and death,
neurodegenerative diseases (NDDs) significantly threaten human health, while no effective …

Targeting PI3K-AKT/mTOR signaling in the prevention of autism

A Sharma, S Mehan - Neurochemistry international, 2021 - Elsevier
Abstract PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism
for mammalian enzyme-related receptors in transducing signals or biological processes …

Naringenin: A prospective therapeutic agent for Alzheimer's and Parkinson's disease

A Goyal, A Verma, N Dubey, J Raghav… - Journal of Food …, 2022 - Wiley Online Library
Neurodegenerative disorders (NDs) are a cluster of progressive, severe, and disabling
disorders that affect millions of people worldwide and are on the surge. These disorders are …

Dietary glucosinolates derived isothiocyanates: chemical properties, metabolism and their potential in prevention of Alzheimer's disease

F Khan, A Joshi, HP Devkota… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent form of dementia affecting millions of people
worldwide. It is a progressive, irreversible, and incurable neurodegenerative disorder that …

The role of insulin signaling in hippocampal-related diseases: a focus on Alzheimer's disease

Q Liu, Z Wang, J Cao, Y Dong, Y Chen - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a global concern and has become a major public health event
affecting human health. Insulin is a metabolic hormone secreted mainly by the peripheral …

Molecular mechanisms and therapeutic potential of icariin in the treatment of Alzheimer's disease

L Zheng, S Wu, H Jin, J Wu, X Wang, Y Cao, Z Zhou… - Phytomedicine, 2023 - Elsevier
Background Icariin (ICA) is the main active component of Epimedium, a traditional Chinese
medicine (TCM), known to enhance cognitive function in Alzheimer's disease (AD). This …

Cdk5 and aberrant cell cycle activation at the core of neurodegeneration

R Requejo-Aguilar - Neural Regeneration Research, 2023 - journals.lww.com
Neurodegenerative diseases are caused by the progressive loss of specific neurons. The
exact mechanisms of action of these diseases are unknown, and many studies have focused …

[HTML][HTML] Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in …

E Sola, P Moyano, A Flores, JM García, J García… - Chemico-Biological …, 2023 - Elsevier
Cadmium (Cd) produces cognition decline following single and repeated treatment,
although the complete mechanisms are still unrevealed. Basal forebrain (BF) cholinergic …