Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …
and mortality in aged population. Several transcription molecules, pathways, and molecular …
Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments
M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …
astrocytes participate in several pathophysiological processes including neuroinflammation …
Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration
Background As common, progressive, and chronic causes of disability and death,
neurodegenerative diseases (NDDs) significantly threaten human health, while no effective …
neurodegenerative diseases (NDDs) significantly threaten human health, while no effective …
Targeting PI3K-AKT/mTOR signaling in the prevention of autism
A Sharma, S Mehan - Neurochemistry international, 2021 - Elsevier
Abstract PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism
for mammalian enzyme-related receptors in transducing signals or biological processes …
for mammalian enzyme-related receptors in transducing signals or biological processes …
Naringenin: A prospective therapeutic agent for Alzheimer's and Parkinson's disease
Neurodegenerative disorders (NDs) are a cluster of progressive, severe, and disabling
disorders that affect millions of people worldwide and are on the surge. These disorders are …
disorders that affect millions of people worldwide and are on the surge. These disorders are …
Dietary glucosinolates derived isothiocyanates: chemical properties, metabolism and their potential in prevention of Alzheimer's disease
F Khan, A Joshi, HP Devkota… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent form of dementia affecting millions of people
worldwide. It is a progressive, irreversible, and incurable neurodegenerative disorder that …
worldwide. It is a progressive, irreversible, and incurable neurodegenerative disorder that …
The role of insulin signaling in hippocampal-related diseases: a focus on Alzheimer's disease
Q Liu, Z Wang, J Cao, Y Dong, Y Chen - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a global concern and has become a major public health event
affecting human health. Insulin is a metabolic hormone secreted mainly by the peripheral …
affecting human health. Insulin is a metabolic hormone secreted mainly by the peripheral …
Molecular mechanisms and therapeutic potential of icariin in the treatment of Alzheimer's disease
L Zheng, S Wu, H Jin, J Wu, X Wang, Y Cao, Z Zhou… - Phytomedicine, 2023 - Elsevier
Background Icariin (ICA) is the main active component of Epimedium, a traditional Chinese
medicine (TCM), known to enhance cognitive function in Alzheimer's disease (AD). This …
medicine (TCM), known to enhance cognitive function in Alzheimer's disease (AD). This …
Cdk5 and aberrant cell cycle activation at the core of neurodegeneration
R Requejo-Aguilar - Neural Regeneration Research, 2023 - journals.lww.com
Neurodegenerative diseases are caused by the progressive loss of specific neurons. The
exact mechanisms of action of these diseases are unknown, and many studies have focused …
exact mechanisms of action of these diseases are unknown, and many studies have focused …
[HTML][HTML] Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in …
Cadmium (Cd) produces cognition decline following single and repeated treatment,
although the complete mechanisms are still unrevealed. Basal forebrain (BF) cholinergic …
although the complete mechanisms are still unrevealed. Basal forebrain (BF) cholinergic …