The ATP-driven chaperone valosin-containing protein (VCP)/p97 governs critical steps in
ubiquitin-dependent protein quality control and intracellular signalling pathways. It …

The hexameric type II AAA ATPase (ATPase associated with various activities) p97 (also
referred to as VCP, Cdc48, and Ter94) is critically involved in a variety of cellular activities …

Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to
malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment …

To ensure survival in the face of genomic insult, cells have evolved complex mechanisms to
respond to DNA damage, termed the DNA damage checkpoint. The serine/threonine …

Cdc48 (p97), a conserved chaperone-like ATPase of eukaryotic cells, has attracted attention
recently because of its wide range of cellular functions. Cdc48 is intimately linked to the …

Methylation is a post-translational modification that can affect numerous features of proteins,
notably cellular localization, turnover, activity, and molecular interactions. Recent genome …

Cdc48/p97, a member of the AAA (ATPase associated with various cellular activities)
ATPase family, participates in various cellular pathways including membrane fusion, protein …

ATM (ataxia telangiectasia-mutated) and ATR (ATM-Rad3-related) are proximal checkpoint
kinases that regulate DNA damage response (DDR). Identification and characterization of …

Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory
functions in a broad array of cellular processes. Working with various cofactors, Cdc48 …

Acquired mutations in the FLT3 receptor tyrosine kinase are common in acute myeloid
leukemia and result in constitutive activation. The most frequent mechanism of activation is …