Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Chalcones represent key structural motif in the plethora of biologically active molecules
including synthetic and natural products. Synthetic manipulations of chalcones or their …

Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …

In spite of the development of a large number of novel anticancer drugs over the years,
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …

Cancer is a leading cause of death and a major health problem worldwide. While many
effective anticancer agents are available, the majority of drugs currently on the market are …

Chalcones are naturally occurring compounds exhibiting broad spectrum biological
activities including anticancer activity through multiple mechanisms. Literature on anticancer …

Quinoxaline, a fused heterocycle of benzene and pyrazine rings has gained considerable
attention in the field of contemporary medicinal chemistry. The moiety is of substantial …

Quinoxaline is a fused heterocycle ring template present in diverse pharmacophore and
widely used in medicinal chemistry. Owing to its vast pharmaceutical profile, several …

Quinoxalines are benzopyrazines containing benzene and pyrazine rings fused together. In
the recent past, quinoxalines have attracted Medicinal Chemists considerably for their …

Glioblastoma multiforme (GBM) is a grade IV astrocytoma with a median survival of 12
months despite current multi-modal treatment options. GBM is distinguished …