Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves
an important scaffolding role at focal adhesions by recruiting structural and signaling …

The formation of epithelial cell barriers results from the defined spatiotemporal differentiation
of stem cells into a specialized and polarized epithelium, a process termed mesenchymal …

Focal adhesions (FAs) are mechanosensitive adhesion and signaling complexes that grow
and change composition in response to myosin II–mediated cytoskeletal tension in a …

Epithelial-mesenchymal transition (EMT) is an essential process that drives polarized,
immotile mammary epithelial cells (MECs) to acquire apolar, highly migratory fibroblastoid …

Metastasis requires tumor cells to navigate through a stiff stroma and squeeze through
confined microenvironments. Whether tumors exploit unique biophysical properties to …

Individual metastatic tumor cells exhibit two interconvertible modes of cell motility during
tissue invasion that are classified as either mesenchymal or amoeboid. The molecular …

Transforming growth factor β (TGF-β)–stimulated epithelial–mesenchymal transition (EMT) is
an important developmental process that has also been implicated in increased cell …

Expression of carbonic anhydrase IX (CA9) was shown to be strongly involved in high
incidences of metastasis and poor prognosis in various human tumors. In this study, we …

Cancer is a multifactorial process associated with changes in signaling pathways leading to
cell cycle variations and gene expression. The transient receptor potential melastatin 8 …

Lung cancer is characterized by abnormal cell growth and invasion, and the actin
cytoskeleton plays a major role in these processes. The focal adhesion protein paxillin is a …