Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

A key challenge in radiotherapy is to maximize radiation doses to cancer cells while
minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients …

The gut microbiome is affected by multiple factors, including genetics. In this study, we
assessed the influence of host genetics on microbial species, pathways and gene ontology …

Genetics provides a potentially powerful approach to dissect host-gut microbiota
interactions. Toward this end, we profiled gut microbiota using 16s rRNA gene sequencing …

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with
body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of …

Genotype imputation is now an essential tool in the analysis of genome-wide association
scans. This technique allows geneticists to accurately evaluate the evidence for association …

To identify genetic factors influencing quantitative traits of biomedical importance, we
conducted a genome-wide association study in 8,842 samples from population-based …

Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were
largely unknown, with the exception of a few forms of monogenic extreme obesity. Since …

In 2007, an association of single nucleotide polymorphisms (SNPs) in the fat mass and
obesity-associated (FTO) gene region with body mass index (BMI) and risk of obesity was …

Body mass index (BMI), a proxy measure for obesity, is determined by both environmental
(including ethnicity, age, and sex) and genetic factors, with> 400 BMI-associated loci …