Association between obesity and risk of fracture, bone mineral density and bone quality in adults: a systematic review and meta-analysis
Background The association between obesity and fracture risk may be skeletal site-and sex-
specific but results among studies are inconsistent. Whilst several studies reported higher …
specific but results among studies are inconsistent. Whilst several studies reported higher …
Obesity and ageing: Two sides of the same coin
Conditions and comorbidities of obesity mirror those of ageing and age‐related diseases.
Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic …
Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic …
OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases
Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with
fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic …
fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic …
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis
Bone marrow adipose tissue (BMAT) comprises> 10% of total adipose mass, yet unlike
white or brown adipose tissues (WAT or BAT) its metabolic functions remain unclear. Herein …
white or brown adipose tissues (WAT or BAT) its metabolic functions remain unclear. Herein …
A revised perspective of skeletal stem cell biology
TH Ambrosi, MT Longaker, CKF Chan - Frontiers in cell and …, 2019 - frontiersin.org
Bone-related maladies are a major health burden on modern society. Loss of skeletal
integrity and regeneration capacity through aging, obesity, and disease follows from a …
integrity and regeneration capacity through aging, obesity, and disease follows from a …
The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity
Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …
Mesenchymal stromal cell-based bone regeneration therapies: from cell transplantation and tissue engineering to therapeutic secretomes and extracellular vesicles
D Marolt Presen, A Traweger, M Gimona… - … in bioengineering and …, 2019 - frontiersin.org
Effective regeneration of bone defects often presents significant challenges, particularly in
patients with decreased tissue regeneration capacity due to extensive trauma, disease …
patients with decreased tissue regeneration capacity due to extensive trauma, disease …
Leptin induces proadipogenic and proinflammatory signaling in adipocytes
L Palhinha, S Liechocki, ED Hottz… - Frontiers in …, 2019 - frontiersin.org
Background: Leptin is an adipokine with well-known effects on the central nervous system
including the induction of energy expenditure and satiety. Leptin also has major relevance …
including the induction of energy expenditure and satiety. Leptin also has major relevance …
Cellular and molecular mechanisms associating obesity to bone loss
YS Forte, M Renovato-Martins, C Barja-Fidalgo - Cells, 2023 - mdpi.com
Obesity is an alarming disease that favors the upset of other illnesses and enhances
mortality. It is spreading fast worldwide may affect more than 1 billion people by 2030. The …
mortality. It is spreading fast worldwide may affect more than 1 billion people by 2030. The …