Acute myeloid leukemia: a comprehensive review and 2016 update
I De Kouchkovsky, M Abdul-Hay - Blood cancer journal, 2016 - nature.com
Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with an
incidence of over 20 000 cases per year in the United States alone. Large chromosomal …
incidence of over 20 000 cases per year in the United States alone. Large chromosomal …
[HTML][HTML] Emerging therapies and novel targets for TDP-43 proteinopathy in ALS/FTD
Nuclear clearance and cytoplasmic mislocalization of the essential RNA binding protein,
TDP-43, is a pathologic hallmark of amyotrophic lateral sclerosis, frontotemporal dementia …
TDP-43, is a pathologic hallmark of amyotrophic lateral sclerosis, frontotemporal dementia …
Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria
Streptomyces bacteria are known for their prolific production of secondary metabolites, many
of which have been widely used in human medicine, agriculture and animal health. To guide …
of which have been widely used in human medicine, agriculture and animal health. To guide …
[HTML][HTML] New drugs before, during, and after hematopoietic stem cell transplantation for patients with acute myeloid leukemia
The treatment of acute myeloid leukemia (AML) has evolved over the past few years with the
advent of next-generation sequencing. Targeted therapies alone or in combination with low …
advent of next-generation sequencing. Targeted therapies alone or in combination with low …
MiR-15a-5p confers chemoresistance in acute myeloid leukemia by inhibiting autophagy induced by daunorubicin
E Bollaert, M Claus, V Vandewalle, S Lenglez… - International journal of …, 2021 - mdpi.com
Anthracyclines remain a cornerstone of induction chemotherapy for acute myeloid leukemia
(AML). Refractory or relapsed disease due to chemotherapy resistance is a major obstacle …
(AML). Refractory or relapsed disease due to chemotherapy resistance is a major obstacle …
[HTML][HTML] Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survival
Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic progenitor cells and the
most common malignant myeloid disorder in adults. Several gene mutations such as in …
most common malignant myeloid disorder in adults. Several gene mutations such as in …
Treatment of acute myeloid leukemia in children: A practical perspective
G Egan, Y Chopra, S Mourad… - Pediatric Blood & …, 2021 - Wiley Online Library
Pediatric acute myeloid leukemia (AML) is a heterogeneous disease that requires a
multifaceted treatment approach. Although outcomes for low‐risk AML have improved …
multifaceted treatment approach. Although outcomes for low‐risk AML have improved …
Trending Drugs Combination to Target Leukemia associated Proteins/Genes: using Graph Neural Networks under the RAIN Protocol
Background Leukemia, a cancer impacting blood-forming tissues such as bone marrow and
the lymphatic system, presents in various forms, affecting children and adults differently. The …
the lymphatic system, presents in various forms, affecting children and adults differently. The …
The efficacy and safety of daunorubicin versus idarubicin combined with cytarabine for induction therapy in acute myeloid leukemia: a meta-analysis of randomized …
H Wang, X Xiao, Q Xiao, Y Lu, Y Wu - Medicine, 2020 - journals.lww.com
Objective: To ascertain the efficacy and safety of daunorubicin combined with cytarabine
comparing with idarubicin combined with cytarabine as a standard induction therapy for …
comparing with idarubicin combined with cytarabine as a standard induction therapy for …
[PDF][PDF] Anthracycline derivatives and their anticancer activity
AA Moiseeva - Apoptosis, 2019 - ineosopen.org
Anthracyclines amount to one of the most effective and wellknown chemotherapeutic agents
used for cancer treatment. However, a range of adverse effects, including cardiotoxicity and …
used for cancer treatment. However, a range of adverse effects, including cardiotoxicity and …