Polyamine biomarkers as indicators of human disease

M Amin, S Tang, L Shalamanova, RL Taylor, S Wylie… - Biomarkers, 2021 - Taylor & Francis
The significant increase of periodontitis, chronic kidney disease (CKD), Alzheimer's disease
and cancer can be attributed to an ageing population. Each disease produces a range of …

Polyamines in the virulence of bacterial pathogens of respiratory tract

R Banerji, P Kanojiya, A Patil… - Molecular oral …, 2021 - Wiley Online Library
Polyamines are positively charged hydrocarbons that are essential for the growth and
cellular maintenance in prokaryotes and eukaryotes. Polyamines have been demonstrated …

The oxidative stress response of Streptococcus pneumoniae: its contribution to both extracellular and intracellular survival

M Hernandez-Morfa, NB Olivero, VE Zappia… - Frontiers in …, 2023 - frontiersin.org
Streptococcus pneumoniae is a gram-positive, aerotolerant bacterium that naturally
colonizes the human nasopharynx, but also causes invasive infections and is a major cause …

Difluoromethylornithine (DFMO) and AMXT 1501 inhibit capsule biosynthesis in pneumococci

MB Ayoola, LA Shack, JH Lee, J Lim, H Eoh… - Scientific Reports, 2022 - nature.com
Polyamines are small cationic molecules that have been linked to various cellular processes
including replication, translation, stress response and recently, capsule regulation in …

Spermidine constitutes a key determinant of motility and attachment of Salmonella Typhimurium through a novel regulatory mechanism

AV Nair, A Singh, Y Devasurmutt, SA Rahman… - Microbiological …, 2024 - Elsevier
Spermidine is a poly-cationic molecule belonging to the family of polyamines and is
ubiquitously present in all organisms. Salmonella synthesizes, and harbours specialized …

Polyamine Synthesis Effects Capsule Expression by Reduction of Precursors in Streptococcus pneumoniae

MB Ayoola, LA Shack, MF Nakamya… - Frontiers in …, 2019 - frontiersin.org
Streptococcus pneumoniae (pneumococcus, Spn) colonizes the human nasopharynx
asymptomatically but can cause infections such as otitis media, and invasive pneumococcal …

Pneumococcal virulence factors in community-acquired pneumonia

C Feldman, R Anderson - Current opinion in pulmonary medicine, 2020 - journals.lww.com
Pneumococcal virulence factors in community-acquired pneumon... : Current Opinion in
Pulmonary Medicine Pneumococcal virulence factors in community-acquired pneumonia …

Acid resistance system CadBA is implicated in acid tolerance and biofilm formation and is identified as a new virulence factor of Edwardsiella tarda

C Du, X Huo, H Gu, D Wu, Y Hu - Veterinary Research, 2021 - Springer
Edwardsiella tarda is a facultative intracellular pathogen in humans and animals. The Gram-
negative bacterium is widely considered a potentially important bacterial pathogen …

SP_0916 Is an Arginine Decarboxylase That Catalyzes the Synthesis of Agmatine, Which Is Critical for Capsule Biosynthesis in Streptococcus pneumoniae

MB Ayoola, MF Nakamya, LA Shack, S Park… - Frontiers in …, 2020 - frontiersin.org
The global burden of invasive pneumococcal diseases, including pneumonia and sepsis,
caused by Streptococcus pneumoniae, a Gram-positive bacterial pathogen, remains a major …

Impact of Difluoromethylornithine and AMXT 1501 on Gene Expression and Capsule Regulation in Streptococcus pneumoniae

MB Ayoola, LA Shack, O Phanstiel IV, B Nanduri - Biomolecules, 2024 - mdpi.com
Streptococcus pneumoniae (Spn), a Gram-positive bacterium, poses a significant threat to
human health, causing mild respiratory infections to severe invasive conditions. Despite the …