High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Dysregulated RNA metabolism is emerging as a crucially important mechanism
underpinning the pathogenesis of frontotemporal dementia (FTD) and the clinically …

A major function of TAR DNA-binding protein-43 (TDP-43) is to repress the inclusion of
cryptic exons during RNA splicing. One of these cryptic exons is in UNC13A, a genetic risk …

The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a diverse family of RNA
binding proteins that are implicated in RNA metabolism, such as alternative splicing, mRNA …

Nuclear depletion of TDP-43, an essential RNA binding protein, may underlie
neurodegeneration in amyotrophic lateral sclerosis (ALS). As several functions have been …

While transcriptional control of innate immune gene expression is well characterized, almost
nothing is known about how pre-mRNA splicing decisions influence, or are influenced by …

Heterogeneous nuclear ribonucleoproteins (HnRNPs) are a group of ubiquitously
expressed RNA-binding proteins implicated in the regulation of all aspects of nucleic acid …

Public archives of next-generation sequencing data are growing exponentially, but the
difficulty of marshaling this data has led to its underutilization by scientists. Here, we present …

Dysfunction of the RNA-binding protein (RBP) FUS implicated in RNA metabolism can
cause amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. Mutations …

Accuracy of pre‐messenger RNA (pre‐mRNA) splicing is crucial for normal gene
expression. Complex regulation supports the spliceosomal distinction between authentic …