Productive cell proliferation involves efficient and accurate splitting of the dividing cell into
two separate entities. This orderly process reflects coordination of diverse cytological events …

In budding yeast, the Mitotic Exit Network (MEN) is a signaling pathway known to drive cells
out of mitosis and promote the faithful division of cells. The MEN triggers inactivation of …

Crossover recombination is essential for accurate chromosome segregation during meiosis.
The MutSγ complex, Msh4-Msh5, facilitates crossing over by binding and stabilizing nascent …

YAP is a transcriptional coactivator that controls organ expansion and differentiation and is
inhibited by the Hippo pathway in cells in interphase. Here, we demonstrated that, during …

The spindle position checkpoint (SPOC) is an essential surveillance mechanism that allows
mitotic exit only when the spindle is correctly oriented along the cell axis. Key SPOC …

In order to preserve genome integrity and their ploidy, cells must ensure that the duplicated
genome has been faithfully replicated and evenly distributed before they complete their …

In budding yeast, a Ras-like GTPase signaling cascade known as the mitotic exit network
(MEN) promotes exit from mitosis. To ensure the accurate execution of mitosis, MEN activity …

Every cell division in budding yeast is inherently asymmetric and counts on the correct
positioning of the mitotic spindle along the mother-daughter polarity axis for faithful …

GTPase signal transduction pathways control cellular decision making by integrating
multiple cellular events into a single signal. The Mitotic Exit Network (MEN), a Ras-like …

Crossing over is essential for chromosome segregation during meiosis. Protein modification
by SUMO is implicated in crossover control, but pertinent targets have remained elusive …