1, 8-naphthyridine derivatives: a privileged scaffold for versatile biological activities
1, 8-Naphthyridine nucleus belongs to significant nitrogen-containing heterocyclic
compounds which has garnered the interest of researchers due to its versatile biological …
compounds which has garnered the interest of researchers due to its versatile biological …
Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α‐glycosidase and molecular docking studies
Aldose reductase (AR) is the first and rate‐limiting enzyme of the polyol pathway, which
converts glucose to sorbitol in an NADPH‐dependent reaction. α‐Glycosidase breaks down …
converts glucose to sorbitol in an NADPH‐dependent reaction. α‐Glycosidase breaks down …
Synthesis, biological activity and docking calculations of bis-naphthoquinone derivatives from Lawsone
Some metabolic enzyme inhibitors can be used as Multi-target-Directed-Ligands (MTDL) in
Medicinal chemistry therefore, synthesis and determination of alternative inhibitors are …
Medicinal chemistry therefore, synthesis and determination of alternative inhibitors are …
Synthesis, bioinformatics and biological evaluation of novel pyridine based on 8-hydroxyquinoline derivatives as antibacterial agents: DFT, molecular docking and …
The present study aims to first explore the relationship between the chemical structure of the
organic compounds (pyridine based on 8-hydroxyquinoline) and the antibacterial activities …
organic compounds (pyridine based on 8-hydroxyquinoline) and the antibacterial activities …
Are clarithromycin, azithromycin and their analogues effective in the treatment of COVID19
BACKGROUND: SARS-CoV-2, which started in Wuhan and later affected the whole world, is
the most important disease of the world today. Many ways to inhibit SARS-CoV-2 virus are …
the most important disease of the world today. Many ways to inhibit SARS-CoV-2 virus are …
The biological activities, molecular docking studies, and anticancer effects of 1-arylsuphonylpyrazole derivatives
This work is devoted to definition of the direction of reaction between 1-
benzenesulfonylimino pyridinium chloride and α-or β-halo-containing sulfamides …
benzenesulfonylimino pyridinium chloride and α-or β-halo-containing sulfamides …
Novel propanolamine derivatives attached to 2-metoxifenol moiety: Synthesis, characterization, biological properties, and molecular docking studies
The synthesis of seven new ß-amino alcohols was designed and performed by starting from
eugenol, a natural phenolic compound known to be biologically active. The synthesized …
eugenol, a natural phenolic compound known to be biologically active. The synthesized …
Novel phenolic Mannich base derivatives: synthesis, bioactivity, molecular docking, and ADME-Tox Studies
In this study, it was aimed to synthesize novel molecules containing potential biological
active phenolic Mannich base moiety and evaluate the inhibition properties against α …
active phenolic Mannich base moiety and evaluate the inhibition properties against α …
Design, synthesis, characterization, biological evaluation, and molecular docking studies of novel 1, 2-aminopropanthiols substituted derivatives as selective carbonic …
A Huseynova, R Kaya, P Taslimi… - Journal of …, 2022 - Taylor & Francis
In the article, various substituted derivatives of 1, 2-aminopropanthiol (1a–g) have been
prepared by a general and efficient method, in one-steps, starting from available thiirane …
prepared by a general and efficient method, in one-steps, starting from available thiirane …
Synthesis, molecular docking, and biological activities of new cyanopyridine derivatives containing phenylurea
H Gezegen, MB Gürdere, A Dinçer… - Archiv der …, 2021 - Wiley Online Library
A new class of cyanopyridine derivatives (10a–e and 11a–e) containing the phenylurea unit
was synthesized and tested against some metabolic enzymes including …
was synthesized and tested against some metabolic enzymes including …