Crosstalk among circRNA/lncRNA, miRNA, and mRNA in osteoarthritis

H Kong, ML Sun, XA Zhang, XQ Wang - Frontiers in Cell and …, 2021 - frontiersin.org
Osteoarthritis (OA) is a joint disease that is pervasive in life, and the incidence and mortality
of OA are increasing, causing many adverse effects on people's life. Therefore, it is very vital …

Research progress on the role of lncRNA–miRNA networks in regulating adipogenic and osteogenic differentiation of bone marrow mesenchymal stem cells in …

F An, X Wang, C Wang, Y Liu, B Sun, J Zhang… - Frontiers in …, 2023 - frontiersin.org
Osteoporosis (OP) is characterized by a decrease in osteoblasts and an increase in
adipocytes in the bone marrow compartment, alongside abnormal bone/fat differentiation …

Long non-coding RNA MIR22HG promotes osteogenic differentiation of bone marrow mesenchymal stem cells via PTEN/ AKT pathway

C Jin, L Jia, Z Tang, Y Zheng - Cell death & disease, 2020 - nature.com
Osteoporosis is a prevalent metabolic bone disease characterized by low bone mineral
density and degenerative disorders of bone tissues. Previous studies showed the abnormal …

The role of extracellular vesicles (EVs) in the epigenetic regulation of bone metabolism and osteoporosis

M Muraca, A Cappariello - International Journal of Molecular Sciences, 2020 - mdpi.com
Extracellular vesicles (EVs) are complex phospholipidic structures actively released by cells.
EVs are recognized as powerful means of intercellular communication since they contain …

Long non-coding RNA KCNQ1OT1 alleviates postmenopausal osteoporosis by modulating miR-421-3p/mTOR axis

Z Wang, H Zhang, Q Li, L Zhang, L Chen, H Wang… - Scientific Reports, 2023 - nature.com
The prevention and treatment of postmenopausal osteoporosis (PMOP) is a significant
public health issue, and non-coding RNAs are of vital importance in this process. In this …

A novel ceRNA regulatory network involving the long noncoding NEAT1, miRNA-466f-3p and its mRNA target in osteoblast autophagy and osteoporosis

X Zhao, D Zhao, B Geng, W Yaobin, Y Xia - Journal of Molecular Medicine, 2022 - Springer
Osteoporosis (OP) is a systemic metabolic disorder characterized by a reduction in bone
tissue volume. LncRNAs have been reported to act as regulators of several human …

RUNX2 regulation in osteoblast differentiation: a possible therapeutic function of the lncRNA and miRNA-mediated network

PN Arya, I Saranya, N Selvamurugan - Differentiation, 2024 - Elsevier
Osteogenic differentiation is a crucial process in the formation of the skeleton and the
remodeling of bones. It relies on a complex system of signaling pathways and transcription …

Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 promotes the osteoblast differentiation of human bone marrow-derived mesenchymal …

LY Zang, XL Yang, WJ Li, GL Liu - Journal of Craniofacial Surgery, 2022 - journals.lww.com
Objectives: To investigate whether and how the long noncoding RNA (lncRNA) metastasis-
associated lung adenocarcinoma transcript 1 (MALAT1) sponges microRNA-96 (miR-96) to …

Knockdown of long non-coding RNA HOTAIR promotes bone marrow mesenchymal stem cell differentiation by sponging microRNA miR-378g that inhibits …

W Wang, T Li, S Feng - Bioengineered, 2021 - Taylor & Francis
Osteoporosis (OP) is associated with a serious social and economic burden. Recent studies
have shown that the differential expression of long non-coding RNAs (lncRNAs) is closely …

Circulating miRNAs: a new opportunity in bone fragility

S Donati, S Ciuffi, G Palmini, ML Brandi - Biomolecules, 2020 - mdpi.com
Osteoporosis, one of the leading causes of bone fractures, is characterized by low bone
mass and structural deterioration of bone tissue, which are associated with a consequent …