The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …

Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450
(CYP) epoxygenases, which include four regioisomers: 5, 6-EET, 8, 9-EET, 11, 12-EET, and …

Arachidonic acid is metabolized by cyclooxygenase, lipoxygenase, and cytochrome P450
enzymes to produce prostaglandins, leukotrienes, epoxyeicosatrienoic acids (EETs), and …

Age-associated changes leading to a decline in cardiac structure and function contribute to
the increased susceptibility and incidence of cardiovascular diseases (CVD) in elderly …

To elucidate molecular mechanisms responsible for the sexually dimorphic phenotype of
soluble epoxide hydrolase (sEH) expression, we tested the hypothesis that female-specific …

Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause
nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents …

Biological aging is an inevitable part of life that has intrigued individuals for millennia. The
progressive decline in biological systems impacts cardiac function and increases …

Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450
(CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH). Circulating …

In recent years, numerous experimental studies have underscored the pivotal role of soluble
epoxide hydrolase (sEH) in renal diseases, demonstrating the reno-protective effects of sEH …

Summary 1 We found recently that in Ren-2 transgenic hypertensive rats (TGR) addition of
soluble epoxide 2 hydrolase inhibitor (sEHi) to treatment with angiotensin-converting …