Cytochrome P450-derived eicosanoids and heart function

KL Jamieson, T Endo, AM Darwesh… - Pharmacology & …, 2017 - Elsevier
The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …

[HTML][HTML] The role of epoxyeicosatrienoic acids in cardiac remodeling

J Lai, C Chen - Frontiers in physiology, 2021 - frontiersin.org
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450
(CYP) epoxygenases, which include four regioisomers: 5, 6-EET, 8, 9-EET, 11, 12-EET, and …

Sex differences in eicosanoid formation and metabolism: a possible mediator of sex discrepancies in cardiovascular diseases

SH Gerges, AOS El-Kadi - Pharmacology & therapeutics, 2022 - Elsevier
Arachidonic acid is metabolized by cyclooxygenase, lipoxygenase, and cytochrome P450
enzymes to produce prostaglandins, leukotrienes, epoxyeicosatrienoic acids (EETs), and …

[HTML][HTML] Mitochondrial dysfunction and inflammaging in heart failure: novel roles of CYP-derived epoxylipids

H Keshavarz-Bahaghighat, AM Darwesh… - Cells, 2020 - mdpi.com
Age-associated changes leading to a decline in cardiac structure and function contribute to
the increased susceptibility and incidence of cardiovascular diseases (CVD) in elderly …

Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation

YM Yang, D Sun, S Kandhi, G Froogh… - Proceedings of the …, 2018 - National Acad Sciences
To elucidate molecular mechanisms responsible for the sexually dimorphic phenotype of
soluble epoxide hydrolase (sEH) expression, we tested the hypothesis that female-specific …

[HTML][HTML] Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice

MKO Grant, DM Seelig, LC Sharkey, WSV Choi… - PLoS …, 2019 - journals.plos.org
Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause
nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents …

[HTML][HTML] Age and sex differences in hearts of soluble epoxide hydrolase null mice

KL Jamieson, H Keshavarz-Bahaghighat… - Frontiers in …, 2020 - frontiersin.org
Biological aging is an inevitable part of life that has intrigued individuals for millennia. The
progressive decline in biological systems impacts cardiac function and increases …

[HTML][HTML] Sexually dimorphic regulation of EET synthesis and metabolism: roles of estrogen

A Huang, D Sun - Frontiers in pharmacology, 2018 - frontiersin.org
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450
(CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH). Circulating …

[HTML][HTML] Regulation of soluble epoxide hydrolase in renal-associated diseases: insights from potential mechanisms to clinical researches

P Gao, Y Cao, L Ma - Frontiers in Endocrinology, 2024 - frontiersin.org
In recent years, numerous experimental studies have underscored the pivotal role of soluble
epoxide hydrolase (sEH) in renal diseases, demonstrating the reno-protective effects of sEH …

[PDF][PDF] Sex-linked differences in the mortality in Ren-2 transgenic hypertensive rats with aorto-caval fistula: effects of treatment with angiotensin converting enzyme …

P Kala, L Červenka, P Škaroupková, M Táborský… - Physiol Res, 2019 - biomed.cas.cz
Summary 1 We found recently that in Ren-2 transgenic hypertensive rats (TGR) addition of
soluble epoxide 2 hydrolase inhibitor (sEHi) to treatment with angiotensin-converting …