Cytochrome P450-derived eicosanoids and heart function
KL Jamieson, T Endo, AM Darwesh… - Pharmacology & …, 2017 - Elsevier
The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …
enzymes, which are important in the metabolism of foreign and endogenous compounds …
[HTML][HTML] The role of epoxyeicosatrienoic acids in cardiac remodeling
J Lai, C Chen - Frontiers in physiology, 2021 - frontiersin.org
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by cytochrome P450
(CYP) epoxygenases, which include four regioisomers: 5, 6-EET, 8, 9-EET, 11, 12-EET, and …
(CYP) epoxygenases, which include four regioisomers: 5, 6-EET, 8, 9-EET, 11, 12-EET, and …
Sex differences in eicosanoid formation and metabolism: a possible mediator of sex discrepancies in cardiovascular diseases
SH Gerges, AOS El-Kadi - Pharmacology & therapeutics, 2022 - Elsevier
Arachidonic acid is metabolized by cyclooxygenase, lipoxygenase, and cytochrome P450
enzymes to produce prostaglandins, leukotrienes, epoxyeicosatrienoic acids (EETs), and …
enzymes to produce prostaglandins, leukotrienes, epoxyeicosatrienoic acids (EETs), and …
[HTML][HTML] Mitochondrial dysfunction and inflammaging in heart failure: novel roles of CYP-derived epoxylipids
H Keshavarz-Bahaghighat, AM Darwesh… - Cells, 2020 - mdpi.com
Age-associated changes leading to a decline in cardiac structure and function contribute to
the increased susceptibility and incidence of cardiovascular diseases (CVD) in elderly …
the increased susceptibility and incidence of cardiovascular diseases (CVD) in elderly …
Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation
To elucidate molecular mechanisms responsible for the sexually dimorphic phenotype of
soluble epoxide hydrolase (sEH) expression, we tested the hypothesis that female-specific …
soluble epoxide hydrolase (sEH) expression, we tested the hypothesis that female-specific …
[HTML][HTML] Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice
Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause
nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents …
nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents …
[HTML][HTML] Age and sex differences in hearts of soluble epoxide hydrolase null mice
KL Jamieson, H Keshavarz-Bahaghighat… - Frontiers in …, 2020 - frontiersin.org
Biological aging is an inevitable part of life that has intrigued individuals for millennia. The
progressive decline in biological systems impacts cardiac function and increases …
progressive decline in biological systems impacts cardiac function and increases …
[HTML][HTML] Sexually dimorphic regulation of EET synthesis and metabolism: roles of estrogen
A Huang, D Sun - Frontiers in pharmacology, 2018 - frontiersin.org
Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid via cytochrome P450
(CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH). Circulating …
(CYP)/epoxygenase and are hydrolyzed by soluble epoxide hydrolase (sEH). Circulating …
[HTML][HTML] Regulation of soluble epoxide hydrolase in renal-associated diseases: insights from potential mechanisms to clinical researches
P Gao, Y Cao, L Ma - Frontiers in Endocrinology, 2024 - frontiersin.org
In recent years, numerous experimental studies have underscored the pivotal role of soluble
epoxide hydrolase (sEH) in renal diseases, demonstrating the reno-protective effects of sEH …
epoxide hydrolase (sEH) in renal diseases, demonstrating the reno-protective effects of sEH …
[PDF][PDF] Sex-linked differences in the mortality in Ren-2 transgenic hypertensive rats with aorto-caval fistula: effects of treatment with angiotensin converting enzyme …
P Kala, L Červenka, P Škaroupková, M Táborský… - Physiol Res, 2019 - biomed.cas.cz
Summary 1 We found recently that in Ren-2 transgenic hypertensive rats (TGR) addition of
soluble epoxide 2 hydrolase inhibitor (sEHi) to treatment with angiotensin-converting …
soluble epoxide 2 hydrolase inhibitor (sEHi) to treatment with angiotensin-converting …