Regulation of endothelial progenitor cell functions during hyperglycemia: new therapeutic targets in diabetic wound healing

G Wan, Y Chen, J Chen, C Yan, C Wang, W Li… - Journal of Molecular …, 2022 - Springer
Diabetes is primarily characterized by hyperglycemia, and its high incidence is often very
costly to patients, their families, and national economies. Unsurprisingly, the number and …

The impact of ATP-binding cassette transporters on metabolic diseases

Z Ye, Y Lu, T Wu - Nutrition & Metabolism, 2020 - Springer
Currently, many people worldwide suffer from metabolic diseases caused by heredity and
external factors, such as diet. One of the symptoms of metabolic diseases is abnormal lipid …

N-cadherin overexpression mobilizes the protective effects of mesenchymal stromal cells against ischemic heart injury through a β-catenin–dependent manner

W Yan, C Lin, Y Guo, Y Chen, Y Du, WB Lau… - Circulation …, 2020 - Am Heart Assoc
Rationale: Mesenchymal stromal cell–based therapy is promising against ischemic heart
failure. However, its efficacy is limited due to low cell retention and poor paracrine function …

CNP ameliorates macrophage inflammatory response and atherosclerosis

Q Bao, B Zhang, L Zhou, Q Yang, X Mu, X Liu… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: CNP (C-type natriuretic peptide), an endogenous short peptide in the
natriuretic peptide family, has emerged as an important regulator to govern vascular …

Conditioned media from endothelial progenitor cells cultured in simulated microgravity promote angiogenesis and bone fracture healing

L Kong, Y Wang, H Wang, Q Pan, R Zuo, S Bai… - Stem cell research & …, 2021 - Springer
Background Paracrine signaling from endothelial progenitor cells (EPCs) is beneficial for
angiogenesis and thus promotes tissue regeneration. Microgravity (MG) environment is …

HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes

R Si, JTO Cabrera, A Tsuji-Hosokawa, R Guo… - JCI …, 2021 - pmc.ncbi.nlm.nih.gov
Patients with diabetes with coronary microvascular disease (CMD) exhibit higher cardiac
mortality than patients without CMD. However, the molecular mechanism by which diabetes …

A protective effect of PPARα in endothelial progenitor cells through regulating metabolism

Y Shao, J Chen, L Dong, X He, R Cheng, K Zhou… - Diabetes, 2019 - Am Diabetes Assoc
Deficiency of endothelial progenitor cells, including endothelial colony-forming cells
(ECFCs) and circulating angiogenic cells (CACs), plays an important role in retinal vascular …

[HTML][HTML] RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma

D Li, L Tang, B Liu, S Xu, M Jin, W Bo - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Abstract Receptor Interacting Serine/Threonine Kinase 2 (RIPK2) is located on chromosome
8q21 and encodes a protein containing a C-terminal caspase activation and recruitment …

A comparative study unraveling the effects of TNF-α stimulation on endothelial cells between 2D and 3D culture

B Wang, R Chen, H Gao, X Lv, L Chen… - Biomedical …, 2020 - iopscience.iop.org
Endothelial cell (EC) dysfunction is an important predictor of and contributor to the
pathobiology of cardiovascular diseases. However, most in vitro studies are performed using …

The role of the tyrosine kinase Lyn in allergy and cancer

Y Sun, Y Yang, Y Zhao, X Li, Y Zhang, Z Liu - Molecular Immunology, 2021 - Elsevier
With worsening air pollution brought by global social development, the prevalence of
allergic diseases has increased dramatically in the past few decades. The novel Lck/yes …