Microbes rely upon iron as a cofactor for many enzymes in their central metabolic processes.
The reactive oxygen species (ROS) superoxide and hydrogen peroxide react rapidly with …

Reactive oxygen species (ROS) have been shown to be toxic but also function as signalling
molecules. This biological paradox underlies mechanisms that are important for the integrity …

Life evolved in an anaerobic world; therefore, fundamental enzymatic mechanisms and
biochemical pathways were refined and integrated into metabolism in the absence of any …

If the atmosphere of the early Earth was hydrogen-rich, 1 it is reasonable to think that
hydrogenases, the enzymes enabling cells to use molecular hydrogen, were probably …

Iron/sulfur centers are key cofactors of proteins intervening in multiple conserved cellular
processes, such as gene expression, DNA repair, RNA modification, central metabolism and …

Oxidative stress, through the production of reactive oxygen species, is a natural
consequence of aerobic metabolism. Escherichia coli has several major regulators activated …

We face an impending crisis in our ability to treat infectious disease brought about by the
emergence of antibiotic-resistant pathogens and a decline in the development of new …

The broad range of cellular activities carried out by Fe–S proteins means that they have a
central role in the life of most organisms. At the interface between biology and chemistry …

Building iron-sulfur (Fe-S) clusters and assembling Fe-S proteins are essential actions for
life on Earth. The three processes that sustain life, photosynthesis, nitrogen fixation, and …

Abstract Iron–sulfur (Fe–S) clusters are ubiquitous metallocofactors involved in redox
chemistry, radical generation and gene regulation. Common methods to monitor Fe–S …