Synthetic Peptides: Promising Modalities for the Targeting of Disease‐Related Nucleic Acids
BD Ellenbroek, JP Kahler, SR Evers… - Angewandte Chemie …, 2024 - Wiley Online Library
DNA and RNA play pivotal roles in life processes by storing and transferring genetic
information, modulating gene expression, and contributing to essential cellular machinery …
information, modulating gene expression, and contributing to essential cellular machinery …
Effects of Molecular Crowding on the Structure, Stability, and Interaction with Ligands of G-quadruplexes
C Gao, HI Mohamed, J Deng, M Umer, N Anwar… - ACS …, 2023 - ACS Publications
G-quadruplexes (G4s) are widely found in cells and have significant biological functions,
which makes them a target for screening antitumor and antiviral drugs. Most of the previous …
which makes them a target for screening antitumor and antiviral drugs. Most of the previous …
Recognition and unfolding of human telomeric G-quadruplex by short peptide binding identified from the HRDC domain of BLM helicase
T Sharma, N Kundu, S Kaur, A Chakraborty… - RSC …, 2022 - pubs.rsc.org
Research in recent decades has revealed that the guanine (G)-quadruplex secondary
structure in DNA modulates a variety of cellular events that are mostly related to serious …
structure in DNA modulates a variety of cellular events that are mostly related to serious …
Significant destabilization of human telomeric G-quadruplex upon peptide binding: dramatic effect of flanking bases
Human telomere is composed of highly repeated hexanucleotide sequence TTAGGG and a
3′ single-stranded DNA tail. Many telomere G4 topologies characterized at atomic level by …
3′ single-stranded DNA tail. Many telomere G4 topologies characterized at atomic level by …
Short designed peptide unfolding human telomeric G-quadruplex: mimicking the helicase function
Human telomeric DNA can fold into G-quadruplex structures involving the interaction of four
guanine bases in a square planar arrangement. The highly distinctive nature of quadruplex …
guanine bases in a square planar arrangement. The highly distinctive nature of quadruplex …
Structural analysis of peptide identified from the 2KRR domain of the nucleolin protein with a c-Myc G4 structure using biophysical and biochemical methods
S Kaur, N Kundu, T Sharma, J Shankaraswamy… - RSC …, 2024 - pubs.rsc.org
For the first time, the c-Myc G4 structure is reported to be stabilized by binding of the peptide
(derived from the 2KRR domain of the nucleolin protein called the Nu peptide) in the loop …
(derived from the 2KRR domain of the nucleolin protein called the Nu peptide) in the loop …
Why to target G‐quadruplexes using peptides: Next‐generation G4‐interacting ligands
T Sharma, N Kundu, S Kaur… - Journal of Peptide …, 2023 - Wiley Online Library
Guanine‐rich oligonucleotides existing in both DNA and RNA are able to fold into four‐
stranded DNA secondary structures via Hoogsteen type hydrogen‐bonding, where four …
stranded DNA secondary structures via Hoogsteen type hydrogen‐bonding, where four …
Peptides and Peptide Derivatives as G‐Quadruplex Targeting Ligands: A Brief Review
Genomic DNA adopts B‐form canonically. Besides, the oligonucleotides can adopt various
non‐canonical secondary structures. These are hairpins, cruciforms, triplexes, quadruplexes …
non‐canonical secondary structures. These are hairpins, cruciforms, triplexes, quadruplexes …
Targeting G4 motifs of various stem cell makers with designed peptide for therapeutic applications
S Kaur, N Kundu, T Sharma, J Shankaraswamy… - Discover Applied …, 2024 - Springer
Noncanonical secondary structures formed by Guanine-rich DNA sequences fold into four-
stranded structures called the G-quadruplexes (G4s). Targeting G-quadruplexes is …
stranded structures called the G-quadruplexes (G4s). Targeting G-quadruplexes is …