Systems biology of angiogenesis signaling: Computational models and omics
Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their
cellular signal transduction, activation, proliferation, differentiation, as well as their …
cellular signal transduction, activation, proliferation, differentiation, as well as their …
Applications of quantitative systems pharmacology in model‐informed drug discovery: perspective on impact and opportunities
EL Bradshaw, ME Spilker, R Zang… - CPT …, 2019 - Wiley Online Library
Quantitative systems pharmacology (QSP) approaches have been increasingly applied in
the pharmaceutical since the landmark white paper published in 2011 by a National …
the pharmaceutical since the landmark white paper published in 2011 by a National …
[HTML][HTML] Computer simulation of TSP1 inhibition of VEGF–akt–eNOS: an angiogenesis triple threat
The matricellular protein thrombospondin-1 (TSP1) is a potent inhibitor of angiogenesis.
Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of …
Specifically, TSP1 has been experimentally shown to inhibit signaling downstream of …
[HTML][HTML] Peripheral blood mononuclear cells extracts VEGF protein levels and VEGF mRNA: Associations with inflammatory molecules in a healthy population
V Gorenjak, DR Vance, AM Petrelis, MG Stathopoulou… - Plos one, 2019 - journals.plos.org
Background Vascular endothelial growth factor (VEGF) is a signal protein, implicated in
various physiological and pathophysiological processes together with other common …
various physiological and pathophysiological processes together with other common …
[PDF][PDF] 2.1. Mechanistic systems biology model of VEGF signaling pathway and its regulation of vascular growth and permeability
H Bazzazi, Y Zhang, M Jafarnejad… - SYSTEMS …, 2024 - jscholarship.library.jhu.edu
12 to Akt. The model further predicts that combination strategy involving depletion of CD47
and inhibition of TSP1 binding to CD47 is necessary for effective recovery of signaling to …
and inhibition of TSP1 binding to CD47 is necessary for effective recovery of signaling to …