This review focuses on the sequence of cellular events leading to calcium signals critical for
phagosome maturation. Immune cells kill microbes by engulfing them in a membrane …

Detecting danger is key to the survival and success of all species. Animal nervous and
immune systems cooperate to optimize danger detection. Preceding studies have …

Mycobacterium tuberculosis remains a significant threat to global health. Macrophages are
the host cell for M. tuberculosis infection, and although bacteria are able to replicate …

Given the manifold ways that depression impairs Darwinian fitness, the persistence in the
human genome of risk alleles for the disorder remains a much debated mystery …

Rationale: A major priority in tuberculosis (TB) is to reduce effective treatment times and
emergence of resistance. Recent studies in macrophages and zebrafish show that inhibition …

Macrophages play a critical role in regulating wound healing and tissue regeneration by
changing their polarization state in response to local microenvironmental stimuli. The native …

Given the ability of M. tuberculosis to survive as an intracellular pathogen and its propensity
to develop resistance to the existing antituberculosis drugs, its treatment requires new …

This review presents the evidence that supports the use of thioridazine (TZ) for the therapy of
a pulmonary tuberculosis infection regardless of its antibiotic resistance status. The …

Mutations of human Ca V 1.2 channel gene were identified only recently. The gain-of-
function mutations were found at two mutually exclusive exons in patients with Timothy …

Abstract Calcium (Ca2+) is a ubiquitous mediator of a multitude of cellular functions in the
central nervous system (CNS). Intracellular Ca2+ is tightly regulated by cells, including entry …