Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues
and to distant organs and is the primary cause of cancer morbidity and mortality. In order to …

The pH of the tumor microenvironment drives the metastatic phenotype and
chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH …

High ambient temperatures are a critical challenge in the poultry industry which is a key
producer of the animal-based food. To evaluate heat stress levels, various parameters have …

Summary c-Myc is known to promote glutamine usage by upregulating glutaminase (GLS),
which converts glutamine to glutamate that is catabolized in the TCA cycle. Here we report …

Many cells in mammals exist in the state of quiescence, which is characterized by reversible
exit from the cell cycle. Quiescent cells are widely reported to exhibit reduced size …

Glutamine is the most abundant free amino acid in the body and is known to play a
regulatory role in several cell specific processes including metabolism (eg, oxidative fuel …

Neutrophils act as first-line-of-defense cells and the reduction of their functional activity
contributes to the high susceptibilityto and severity of infections in diabetes mellitus. Clinical …

Inflammatory bowel disease (IBD) is a multifactorial chronic disease, commonly associated
with alteration in the composition and function of gut microbiota. This process can lead to a …

Objective: This article provides a critical review of the evidence indicating that an increase in
intestinal permeability is associated with the installation of bacteremia, sepsis, and the …