Obesity is a pandemic and a serious global health concern. Obesity is a risk factor for
multiple conditions and contributes to multi-morbidities, resulting in increased health costs …

Progress in molecular genetics has changed cardiovascular research. The mouse has
turned out to be an invaluable model for mammalian genetic modifications to mimic and …

Essential hypertension is a common human disease believed to reautt from the interplay of
multiple genetic and environmental determinants. In genetic studies of two large panels of …

We have validated a noninvasive computerized tail-cuff system for measuring blood
pressure in mice. The system was designed to perform all functions automatically, including …

Variants of the human angiotensinogen gene have been linked in some studies to increased
circulating angiotensinogen levels and essential hypertension. To test for direct causality …

Hypertension is a multifactorial disease involving complex interactions between genetic and
environmental factors. Development of experimental models of hypertension allowed …

A reaction between enzyme renin and its only natural substrate angiotensinogen is the initial
and rate-limiting step for producing a potent vasoconstrictor angiotensin II as the final …

Hypertension is a common and complex human disease that causes significant morbidity
and mortality worldwide. Unfortunately, despite recent advances in understanding and …

A brain renin angiotensin system (RAS) and its role in cardiovascular control and fluid
homeostasis was at first controversial. This was because a circulating kidney-derived renin …

It is unknown whether ischemic preconditioning (PC; either early or late) occurs in the
mouse. The goal of this study was to answer this question and to develop a reliable and …