Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1

SD Ludwig, B Meksiriporn, J Tan, R Kureshi… - Cell chemical …, 2024 - cell.com
Summary Programmed death-ligand 1 (PD-L1) drives inhibition of antigen-specific T cell
responses through engagement of its receptor programmed death-1 (PD-1) on activated T …

Distinct interactions stabilize EGFR dimers and higher-order oligomers in cell membranes

KC Mudumbi, EA Burns, DJ Schodt, ZO Petrova… - Cell reports, 2024 - cell.com
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase with important
roles in many cellular processes as well as in cancer and other diseases. EGF binding …

Interrogation of the molecular mechanisms that finetune FcεRI signaling and mast cell outcomes

DA Rinaldi - 2023 - digitalrepository.unm.edu
FcεRI is the ITAM receptor primarily responsible for the allergic response and immune
hypersensitivity diseases such as asthma. Regulation of the strength of both FcεRI signaling …

[PDF][PDF] A review of computational reconstruction of interaction in superresolution microscopy: from colocalization to closing the multichannel gap

B Cardoena, HB Yeddera, IR Nabib, G Hamarneha - researchgate.net
Cellular function is defined by pathways that, in turn, are determined by distance-mediated
interactions between and within subcellular organelles, protein complexes, and …