We have previously characterized in Chinese hamster lung fibroblasts a growth factor
activatable and amiloride-sensitive Na+/H+ antiport (Pouysségur, J., Chambard, JC, Franchi …

The effects of amiloride, a reported inhibitor of serum-stimulated sodium influx, were tested
on tumor growth, tumor cell proliferation, and intracellular element content of cancer cells in …

Amiloride, a Na+ influx inhibitor, has been shown to inhibit initiation of DNA synthesis by
thrombin in mouse embryo fibroblast‐like cells. Long exoosures (24 hr) to high …

Publisher Summary This chapter presents genetic and biochemical evidence establishing
that the Na+–H+ antiporter is a major pH i-regulating system in fibroblasts, that growth …

Animal cell biologists have been preoccupied during the last 20 years with attempts to
understand mechanisms that control normal and cause abnormal growth. This is not …

One would have thought that the strikingly asymmetric distribution of potassium and sodium
ions in cells with K always much higher than Na would have led, early on, to speculation …

Cytotoxicity of tumor necrosis factor (TNF) on L929s cells was efficiently blocked by several
amiloride analogs but not by amiloride itself. This protection did not require RNA or protein …

Benzamil, a drug reported to block passive Na+ transport, also inhibits progesterone-
induced maturation of Xenopus oocytes when given early in the maturation period. The …

Ultimate carcinogens are usually very reactive electrophilic species and therefore of
transient existence in the cell. Both because of the biological reactivity and the inherent …

Publisher Summary Biochemical events associated with lymphocyte activation are initiated
on the binding of ligand or lectin to the cell surface, leading to a cascade of signals …