Bone metastasis is a debilitating side effect of advanced prostatic carcinoma impacting
nearly all of the men developing this disease. Even though a majority of these lesions are …

Cellular subpopulations in the bone marrow play distinct and unexplored functions in
skeletal homeostasis. This study delineated a unique role of osteal macrophages in bone …

The immune response is complex, multifactorial, individualized and often unpredictable.
There are multiple interconnected systems that allow a balance between physiological …

Hematopoietic stem and progenitor cell (HSPC) homeostasis declines with age, leading to
impaired hematopoiesis. Mesenchymal stromal cells (MSC) are critical components of the …

Primary hyperthyroidism (PHPT) is a relatively uncommon disease and leads to increased
calcium levels. Ionized calcium, known as clotting Factor IV, may lead to overt coagulation …

In the tumor microenvironment, CD11b+ Gr1+ bone marrow–derived cells are a
predominant source of protumorigenic factors such as matrix metalloproteinases (MMP), but …

In most tissues, the prevailing view is that stem cell (SC) niches are generated by signals
from within the nearby tissue environment. Here, we define genetic changes altered in hair …

Intermittent parathyroid hormone (iPTH) treatment expands hemopoietic stem and
progenitor cells (HSPCs), but the involved mechanisms and the affected HSPC populations …

Background Periodontitis is an inflammatory disease of the periodontal tissues that
compromises tooth support and can lead to tooth loss. Although bacterial biofilm is central in …

Both PTH and IL-6 signaling play pivotal roles in hematopoiesis and skeletal biology, but
their interdependence is unclear. The purpose of this study was to evaluate the effect of IL-6 …