Progress and development of carbazole scaffold based as potential anti-alzheimer agents using MTDL approach
Alzheimer's is a neurodegenerative disease (NDs) found in old age people with associated
most common symptom dementia. MTDLs (Multi-Target Direct Ligand strategy) is based on …
most common symptom dementia. MTDLs (Multi-Target Direct Ligand strategy) is based on …
Progress and development of C-3, C-6, and N-9 positions substituted carbazole integrated molecular hybrid molecules as potential anticancer agents
The carbazole skeleton, a key structural motif occurring naturally or chemically synthesized,
showed various biological activities. Molecular hybridization based on the combination of …
showed various biological activities. Molecular hybridization based on the combination of …
Insight into structural topology and supramolecular assembly of tetrahydrocarbazole-carbonitrile: On the importance of noncovalent interactions and urease inhibitory …
Organic crystals hold a significant importance in pharmaceuticals, biological systems and
functional materials. In the present study, a tricyclic aromatic structure, tetrahydrocarbazole …
functional materials. In the present study, a tricyclic aromatic structure, tetrahydrocarbazole …
Proteasome mediated degradation of CDC25C and Cyclin B1 in Demethoxycurcumin treated human glioma U87 MG cells to trigger G2/M cell cycle arrest
Recently, we have reported that Demethoxycurcumin induced Reactive oxygen species via
inhibition of Mitochondrial Superoxide Dismutase is an initial event to trigger apoptosis …
inhibition of Mitochondrial Superoxide Dismutase is an initial event to trigger apoptosis …
Design, synthesis, DNA binding studies and evaluation of anticancer potential of novel substituted biscarbazole derivatives against human glioma U87 MG cell line
In this research paper, we report the design and synthesis of novel substituted biscarbazole
derivatives which were characterized by 1 H and 13 C NMR, high resolution mass …
derivatives which were characterized by 1 H and 13 C NMR, high resolution mass …
Demethoxycurcumin mediated targeting of MnSOD leading to activation of apoptotic pathway and inhibition of Akt/NF-κB survival signalling in human glioma U87 MG …
Earlier, we reported that Demethoxycurcumin (DMC) suppressed the growth of human
glioma U87 MG cells by downregulation of Bcl-2 expression. In the present work, we …
glioma U87 MG cells by downregulation of Bcl-2 expression. In the present work, we …
Role of vinca alkaloids and their derivatives in cancer therapy
Vinca alkaloids and its derivatives like Vincristine, Vinblastine etc. isolated from
Catharanthus roseus plants are widely used in the treatment of various types of cancers …
Catharanthus roseus plants are widely used in the treatment of various types of cancers …
A review on synthesis methods of tricyclic 1, 2, 3, 4-tetrahydrocarbazoles
In this review article, we discussed old to new synthetic methods used for the preparation of
1, 2, 3, 4-Tetrahydrocarbazole (THCz) based on reported literature. Around the worldwide …
1, 2, 3, 4-Tetrahydrocarbazole (THCz) based on reported literature. Around the worldwide …
Anticancer Tetrahydrocarbazoles: A Wide Journey from 2000 Till Date
Tetrahydrocarbazoles (THCz) are widespread in numerous indole alkaloids and have been
reported since time for exhibiting profound pharmacological potential. Many …
reported since time for exhibiting profound pharmacological potential. Many …
A Review of In Vitro Antimicrobial Activities of Carbazole and its Derivative From 2014 to 2022
A large number of antibiotics are easily accessible for the treatment of various microbial
infections. However, antibiotic resistance has become a major concern to public health …
infections. However, antibiotic resistance has become a major concern to public health …