The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …

The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …

Embryogenesis involves orchestrated processes of cell proliferation and differentiation. The
mammalian Hes basic helix-loop-helix repressor genes play central roles in these …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Pancreatic development represents a fascinating process in which two morphologically
distinct tissue types must derive from one simple epithelium. These two tissue types …

Mammalian epidermis consists of a basal layer of proliferative progenitors that gives rise to
multiple differentiating layers to provide a waterproof envelope covering the skin surface. To …

The Notch signaling pathway is among the most commonly used communication channels
in animal cells. Recent studies have demonstrated that this pathway is indispensable for …