In patients affected by Parkinson's disease (PD), the most common neurodegenerative
movement disorder, the brain is characterized by the loss of dopaminergic neurons in the …

Within 1 millisecond of action potential arrival at presynaptic terminals voltage–gated Ca2+
channels open. The Ca2+ channels are linked to synaptic vesicles which are tethered by …

Presynaptic active zones are molecular machines that control neurotransmitter secretion.
They form sites for vesicle docking and priming and couple vesicles to Ca 2+ entry for …

Synapses maintain two forms of neurotransmitter release to support communication in the
brain. First, evoked neurotransmitter release is triggered by the invasion of an action …

Synaptotagmin-1 (SYT1) is a synaptic vesicle resident protein that interacts via its C2
domain with anionic lipids from the plasma membrane in a calcium-dependent manner to …

Active zones consist of protein scaffolds that are tightly attached to the presynaptic plasma
membrane. They dock and prime synaptic vesicles, couple them to voltage-gated Ca 2+ …

It is widely believed that information storage in neuronal circuits involves nanoscopic
structural changes at synapses, resulting in the formation of synaptic engrams. However …

An action potential (AP) triggers neurotransmitter release from synaptic vesicles (SVs)
docking to a specialized release site of presynaptic plasma membrane, the active zone (AZ) …

The interaction of post-traumatic stress disorder (PTSD) and atherosclerosis (AS) increase
the risk of mortality. Metabolism and immunity play important roles in the comorbidity …

Abstract Syntaxin-1 (STX1) and Munc18-1 are two requisite components of synaptic
vesicular release machinery, so much so synaptic transmission cannot proceed in their …