Gulf War illness: mechanisms underlying brain dysfunction and promising therapeutic strategies

B Dickey, LN Madhu, AK Shetty - Pharmacology & therapeutics, 2021 - Elsevier
Abstract Gulf War Illness (GWI), a chronic multisymptom health problem, afflicts~ 30% of
veterans served in the first GW. Impaired brain function is among the most significant …

Acetylcholinesterase inhibitor exposures as an initiating factor in the development of Gulf War Illness, a chronic neuroimmune disorder in deployed veterans

LT Michalovicz, KA Kelly, K Sullivan, JP O'Callaghan - Neuropharmacology, 2020 - Elsevier
Abstract Gulf War Illness (GWI) is a chronic multi-symptom disorder, characterized by
symptoms such as fatigue, pain, cognitive and memory impairment, respiratory, skin and …

Dysregulated cholinergic signaling inhibits oligodendrocyte maturation following demyelination

R Ravichandar, F Gadelkarim, R Muthaiah… - Journal of …, 2024 - jneurosci.org
Dysregulation of oligodendrocyte progenitor cell (OPC) recruitment and oligodendrocyte
differentiation contribute to failure of remyelination in human demyelinating diseases such …

[HTML][HTML] FDA-approved cannabidiol [Epidiolex®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and …

M Kodali, LN Madhu, VSV Kolla, S Attaluri… - Military Medical …, 2024 - Springer
Chronic Gulf War Illness (GWI) is characterized by cognitive and mood impairments, as well
as persistent neuroinflammation and oxidative stress. This study aimed to investigate the …

A review of pre-clinical models for Gulf War Illness

ACR Ribeiro, LS Deshpande - Pharmacology & therapeutics, 2021 - Elsevier
Abstract Gulf War Illness (GWI) is a chronic multisymptomatic disorder that afflicts over 1/3rd
of the 1991 GW veterans. It spans multiple bodily systems and presents itself as a syndrome …

Impact of gulf war toxic exposures after mild traumatic brain injury

S Ferguson, R McCartan, M Browning… - Acta Neuropathologica …, 2022 - Springer
Chemical and pharmaceutical exposures have been associated with the development of
Gulf War Illness (GWI), but how these factors interact with the pathophysiology of traumatic …

Alterations in high-order diffusion imaging in veterans with Gulf War Illness is associated with chemical weapons exposure and mild traumatic brain injury

CH Cheng, BB Koo, S Calderazzo, E Quinn… - Brain, behavior, and …, 2020 - Elsevier
The complex etiology behind Gulf War Illness (GWI) has been attributed to the combined
exposure to neurotoxicant chemicals, brain injuries, and some combat experiences. Chronic …

Using plasma autoantibodies of central nervous system proteins to distinguish veterans with gulf war illness from healthy and symptomatic controls

MB Abou-Donia, ES Lapadula, MH Krengel, E Quinn… - Brain sciences, 2020 - mdpi.com
For the past 30 years, there has been a lack of objective tools for diagnosing Gulf War Illness
(GWI), which is largely characterized by central nervous system (CNS) symptoms emerging …

Icaritin Promotes Myelination by Simultaneously Enhancing the Proliferation and Differentiation of Oligodendrocyte Precursor Cells

F Yang, H Wen, S Ma, Q Chang, R Pan, X Liu, Y Liao - Molecules, 2023 - mdpi.com
Myelin repair, which is known as remyelination, is critical to the treatment of
neurodegenerative diseases, and myelination depends on not only the differentiation of …

Longitudinal assessment of health symptoms in relation to neurotoxicant exposures in 1991 Gulf War Veterans: The Ft. Devens Cohort

MK Yee, CG Zundel, AL Maule, T Heeren… - … of occupational and …, 2020 - journals.lww.com
Objective: This analysis examined the relationship between Gulf War (GW) exposures and
health symptoms reported in three time periods over 20 years in Ft. Devens Cohort veterans …