The emergence of universal chromatographic methods in the research and development of new drug substances

EL Regalado, IA Haidar Ahmad, R Bennett… - Accounts of chemical …, 2019 - ACS Publications
Conspectus Manufacturing process development of new drug substances in the
pharmaceutical industry combines numerous chemical challenges beyond the efficient …

Preparation of silica-based superficially porous silica and its application in enantiomer separations: a review

Z Liu, K Quan, H Li, J Chen, M Guan, H Qiu - Journal of Analysis and …, 2021 - Springer
Chromatographic substrate material, as a carrier of chromatographic stationary phases,
plays a vital role in defining its chromatographic characteristics, including column efficiency …

Bimodal single-atom iron nanozyme biosensor for volatile amine and food freshness detection

G Song, Z Zhang, ML Fauconnier, C Li, L Chen… - Nano Today, 2023 - Elsevier
Volatile amines (VAs) play a critical role in detecting the freshness of meat. However, the
development of nondestructive, real-time, and portable techniques for monitoring VAs …

Platform headspace gas chromatography method for high-throughput determination of residual solvents in pharmaceutical materials

L Zou, X Guo, JD McElderry - Journal of pharmaceutical and biomedical …, 2023 - Elsevier
Static headspace capillary gas chromatography (HSGC) has been employed to monitor the
level of residual solvents in the pharmaceutical materials. Most of the HSGC methods …

Individual and simultaneous electroanalytical sensing of epinephrine and lidocaine using an anodically pretreated boron-doped diamond electrode by square-wave …

PT Pınar, Y Yardım, Z Şentürk - Diamond and Related Materials, 2020 - Elsevier
In this study, the individual and simultaneous determination of lidocaine (LID) and
epinephrine (EP) were examined using an anodically pretreated boron-doped diamond …

Generic anion-exchange chromatography method for analytical and preparative separation of nucleotides in the development and manufacture of drug substances

FR Tsay, IAH Ahmad, D Henderson… - … of Chromatography A, 2019 - Elsevier
Nucleotides are among the most frequently used chemical building blocks in the research,
development and manufacture of drug substances. They are composed of three highly polar …

A butterfly shaped Eu 4 (OH) 2 cluster-based luminescent metal–organic framework with Lewis basic triazole sites demonstrating turn off sensing in the presence of …

JR Wang, J Fu, YJ Zhang, JC Liang, RS Zhou… - Dalton …, 2023 - pubs.rsc.org
The effective detection of organic amines is particularly important for environmental
protection and human health. Herein, according to hard and soft acid base theory, a novel …

Derivatization‐free determination of short‐chain volatile amines in human plasma and urine by headspace gas chromatography‐mass spectrometry

P Neyer, L Bernasconi, JA Fuchs… - Journal of clinical …, 2020 - Wiley Online Library
Background Short‐chain volatile amines (SCVA) are an interesting compound class playing
crucial roles in physiological and toxicological human settings. Dimethylamine (DMA) …

Electric-field enhancement of molecularly imprinted sol–gel-coated Au nano-urchin sensors for vapor detection of plant biomarkers

B Chen, C Liu, L Shang, H Guo, J Qin, L Ge… - Journal of Materials …, 2020 - pubs.rsc.org
Detection of plant volatile organic compounds (VOCs) provides a new approach for real-
time, on-field crop growth monitoring in agriculture. Gold (Au) nano-urchins with branched …

[HTML][HTML] Development of a rapid GC-FID method to simultaneously determine triethylamine, diisopropylamine, and 1, 1, 3, 3-tetramethylguanidine residues in an active …

M Shou, H Qiu - Journal of Pharmaceutical Analysis, 2021 - Elsevier
Abstract A rapid GC-FID method was developed to simultaneously determine residual levels
of triethylamine (TEA), 1, 1, 3, 3-tetramethylguanidine (TMG), and diisopropylamine (DIPA) …