Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

A growing amount of evidence indicates that the neuronally expressed developmentally
downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a …

The tumor suppressor PTEN was originally identified as a negative regulator of the
phosphoinositide 3-kinase (PI3K) signaling, a main regulator of cell growth, metabolism and …

The PTEN tumour suppressor is a lipid and protein phosphatase that inhibits
phosphoinositide 3-kinase (PI3K)-dependent signalling by dephosphorylating …

Regulated protein degradation via the ubiquitin-proteasome system (UPS) plays a central
role in building synaptic connections, yet little is known about either which specific UPS …

Tumor suppressor activation or reactivation has long been a sought-after, yet elusive,
therapeutic strategy for human cancer. Phosphatase and tensin homolog (PTEN) is one of …

Protein ubiquitination is a core regulatory determinant of neural development. Previous
studies have indicated that the Nedd4-family E3 ubiquitin ligases Nedd4-1 and Nedd4-2 …

Globally, brucellosis is a widespread zoonotic disease. It is prevalent in more than 170
countries and regions. It mostly damages an animal's reproductive system and causes …

The HECT domain-containing E3 ubiquitin ligase NEDD4-1 (Neural precursor cell
Expressed Developmentally D own regulated gene 4-1) is frequently overexpressed in …

The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase
dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the …