[HTML][HTML] Mitochondrial dysfunction and oxidative stress in Alzheimer's disease

A Misrani, S Tabassum, L Yang - Frontiers in aging neuroscience, 2021 - frontiersin.org
Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

PINK1/Parkin-mediated mitophagy in neurodegenerative diseases

J Li, D Yang, Z Li, M Zhao, D Wang, Z Sun, P Wen… - Ageing research …, 2023 - Elsevier
Mitochondria play key roles in bioenergetics, metabolism, and signaling; therefore, stable
mitochondrial function is essential for cell survival, particularly in energy-intensive neuronal …

Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling

Y Wu, M Chen, J Jiang - Mitochondrion, 2019 - Elsevier
Mitochondrial dysfunction is becoming one of the most emerging pathological process in the
etiology of neurological disorders. Other common etiologies of the neurological disorders …

Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: an update on current advances and …

MU Rehman, N Sehar, NJ Dar, A Khan, A Arafah… - Neuroscience & …, 2023 - Elsevier
Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …

Chondrocyte apoptosis in the pathogenesis of osteoarthritis

HS Hwang, HA Kim - International journal of molecular sciences, 2015 - mdpi.com
Apoptosis is a highly-regulated, active process of cell death involved in development,
homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as …

Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment

M Golpich, E Amini, Z Mohamed… - CNS neuroscience & …, 2017 - Wiley Online Library
Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

[HTML][HTML] Molecular targets of cannabidiol in neurological disorders

CI Bih, T Chen, AVW Nunn, M Bazelot, M Dallas… - …, 2015 - Elsevier
Cannabis has a long history of anecdotal medicinal use and limited licensed medicinal use.
Until recently, alleged clinical effects from anecdotal reports and the use of licensed …

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway

C Holze, C Michaudel, C Mackowiak, DA Haas… - Nature …, 2018 - nature.com
Reactive oxygen species (ROS) are generated by virus-infected cells; however, the
physiological importance of ROS generated under these conditions is unclear. Here we …

Functional mitochondria in health and disease

PM Herst, MR Rowe, GM Carson… - Frontiers in …, 2017 - frontiersin.org
The ability to rapidly adapt cellular bioenergetic capabilities to meet rapidly changing
environmental conditions is mandatory for normal cellular function and for cancer …

Epigenetics of Alzheimer's disease

M Nikolac Perkovic, A Videtic Paska, M Konjevod… - Biomolecules, 2021 - mdpi.com
There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …