New appetite‐regulating antiobesity treatments such as semaglutide and agents under
investigation such as tirzepatide show promise in achieving weight loss of 15% or more …

The current obesity pandemic results from a physiological imbalance in which energy intake
chronically exceeds energy expenditure (EE), and prevention and treatment strategies …

Calorie restriction (CR) is the most potent, non-pharmacological intervention to support
metabolic health. The effects of calorie restriction exceed weight loss. Consistent throughout …

One of the fundamental challenges in obesity research is to identify subjects prone to weight
gain so that obesity and its comorbidities can be promptly prevented or treated. The …

Conservation of the energy equilibrium can be considered a dynamic process and variations
of one component (energy intake or energy expenditure) cause biological and/or behavioral …

Body weight is under physiological regulation. When body fat mass decreases, a series of
responses are triggered to promote weight regain by increasing food intake and decreasing …

Why do so many people become overweight and obese and why do they find it so difficult to
lose weight? In this second edition of his influential book on Dieting, Overweight and …

Low protein diets are associated with increased lifespan and improved cardiometabolic
health primarily in rodents, and likely improve human health. There is strong evidence that …

Background Adaptive thermogenesis during prolonged energy deficit refers to the greater
than expected reduction in energy expenditure (EE) independent of concomitant loss of …

Humans require energy to sustain their daily activities throughout their lives. This narrative
review aims to (a) summarize principles and methods for studying human energy …