Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …

Despite mixed findings, increasing evidence suggests that people with first-episode
psychosis (FEP) show increased pro-inflammatory and pro-oxidative status. We used the …

Although the precise pathogenesis of schizophrenia is unknown, genetic, biomarker and
imaging studies suggest involvement of the immune system. In this study, we performed a …

Background Major depressive disorder is associated with raised peripheral inflammatory
markers. Mounting evidence also suggests that inflammation is involved in suicidal …

BackgroundConverging lines of evidence implicate an important role for the immune system
in schizophrenia. Microglia are the resident immune cells of the central nervous system and …

In this article, we review current evidence linking immune dysfunction in schizophrenia and
related psychotic disorders focusing particularly on circulating cytokines, oxidative stress …

Recent studies suggested that microglia, the primary brain immune cells, can affect circuit
connectivity and neuronal function,. Microglia infiltrate the neuroepithelium early in …

An interaction between external stressors and intrinsic vulnerability is one of the longest
standing pathoaetiological explanations for schizophrenia. However, novel lines of evidence …

The role of immune activation in psychiatric disorders has attracted considerable attention
over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the …

Infections and inflammatory processes have been associated with the development of
schizophrenia and affective disorders; however, no study has yet systematically reviewed all …