Perivascular spaces include a variety of passageways around arterioles, capillaries and
venules in the brain, along which a range of substances can move. Although perivascular …

Vascular cognitive impairment (VCI) is predominately caused by vascular risk factors and
cerebrovascular disease. VCI includes a broad spectrum of cognitive disorders, from mild …

Importance Covert vascular brain injury (VBI) is highly prevalent in community-dwelling
older persons, but its clinical and therapeutic implications are debated. Objective To better …

Until recent years, cerebral small vessel disease (SVD) has drawn little attention mostly
because small cerebral arteries were difficult to observe in imaging and in vivo studies …

In this article, we provide an overview of current neuroimaging methods for studying
perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing …

Objective Adults with Down syndrome (DS) develop Alzheimer disease (AD) pathology by
their 5th decade. Compared with the general population, traditional vascular risks in adults …

Background and Purpose—In the general population, we investigated the association of a
recently developed cerebral small vessel disease (CSVD) sum score with stroke, dementia …

Background Although previously thought to be asymptomatic, recent studies have
suggested that magnetic resonance imaging–visible perivascular spaces (PVS) in the basal …

Clearance of perivascular wastes in the brain may be critical to the pathogenesis of
amyloidopathies. Enlarged perivascular spaces (ePVS) on MRI have also been associated …

Objective To develop, replicate, and validate an MRI-based quantitative measure of both
cerebrovascular and neurodegeneration in Alzheimer disease (AD) for clinical and …